Hematology

Massimiliano Bonifacio
Temporary Assistant Professor
Lucia De Franceschi
Associate Professor
Mauro Krampera
Full Professor
Cristina Tecchio
Assistant Professor
Skills
Topic People Description
red cell disorders and pathologic erythropoiesis Lucia De Franceschi
My scientific activity has focused on red cell pathologies, normal and pathologic erythropoiesis, hemoglobinopathies such as β-thalassemic syndromes and sickle cell disease (SCD) and hereditary rare anemias (i.e.: stomatocytosis, CDAII). An additional area of investigation is chorea-acanthocytosis and McLeod syndrome, which are neurodegenerative disorders involving also the erythroid compartment (Blood 118: 5652-63, 2011; Blood 128: 2976, 2016; J Neurosci 36: 12027, 2016). Through highly productive collaborations and keywork in my laboratory, my research has resulted in a number of breakthrough technologies and discoveries.
immunophenotype of acute and chronic leukemias Mauro Krampera
immunophenotypic characterization of acute and chronic leukemias
immunophenotype in malignant and non-malignant conditions Mauro Krampera
immunophenotypic and functional characterization and sorting of lymphoid subsets in peripheral blood and normal hemato-lymphopoietic tissues and in a number of malignant and non-malignant conditions
flow-cytometric monitoring of minimal residual disease Mauro Krampera
clinical application of flow-cytometric monitoring of minimal residual disease (MRD) in acute leukemia patients; he coordinated the use of this approach also in an Italian multicentre study (GIMEMA LAL0496)
myeloproliferative neoplasms Massimiliano Bonifacio
Efficacy and safety of target therapies in myeloproliferative neoplasms defined by specific genetic and/or molecular markers (i.e. BCR-ABL for chronic myeloid leukemia, KIT for systemic mastocytosis, JAK2, MPL and CALR for Philadelphia-negative myeloproliferative neoplasms); predictive biomarkers of target therapies; immunotherapy of hematologic diseases.
Experimental studies in leukemias, lymphomas and multiple myeloma Mauro Krampera
Cristina Tecchio
In vitro studies on new therapeutic agents

Activities

Research facilities