Development of a new anti-inflammatory pharmacological approach for the treatment of septic shock

Starting date
September 1, 2006
Duration (months)
12
Managers or local contacts
Laudanna Carlo
Keyword
Septic shock, Leukocyte recruitment, Cytokine, Oxidative stress, Signal transduction

  1. Identification and characterization of novel V-ATPases inhibitors able to interfere adhesive and pro-inflammatory activities of leukocytes in in vitro assays.
    1. Effect of V-ATPase inhibitors on rapid integrin activation and dependent adhesion
    2. Effect of V-APTase inhibitors on chemotaxis
    3. Effect of V-APTase inhibitors on generation of oxygen free-radicals (oxidative stress)
    4. Effect of V-ATPase inhibitors on pro-inflammatory cytokine production
  2. Pharmacological characterization of the capability of V-ATPases inhibitors onset and/or to reduce the severity of septic shock in animal models.
    1. Effect of V-ATP-ase inhibitors on onset and progression of septic shock
    2. Identification of compound-related activity, best dosage and toxic effect

Sponsors:

Funds: assigned and managed by the department

Project participants

Simone Dorothea Bach
Matteo Bolomini Vittori
Gabriela Constantin
Full Professor
Cinzia Giagulli
Carlo Laudanna
Full Professor
Marianna Martinello
Barbara Rossi

Activities

Research facilities