Detection of drug-induced signatures in normal and in tumour cells by Fourier Transform InfraRed Microspectroscopy (FTIRM).

Starting date
February 29, 2008
Duration (months)
12
Managers or local contacts
Bellisola Giuseppe

To identify early biochemical and morphological effects of anticancer drugs targeting intracellular signaling networks by FTIRM at single cell and sub-cellular levels. To develop procedures and optimize instrumental setup for the potential application of FTIRM to pre-clinical drug screening assays in cell models and to identify drug-resistant cancer cell subpopulations in leukaemic patients.

Project participants

Giuseppe Bellisola
Gabriella Bergamini
Carlo Laudanna
Full Professor
Claudio Sorio
Associate Professor

Collaboratori esterni

Lisa Vaccari
Elettra Synchrotron Light Source Trieste IR beamline SISSI
Giovanni Birarda
Elettra Synchrotron Light Source Trieste IR beamline SISSI
Publications
Title Authors Year
Development of FT-IR microspectroscopy for pre-clinical and clinical applications Bellisola G.; Bergamini G. ; Bolomini-Vittori M.; Cestelli Guidi M.; Cinque G.; Della Peruta M. ; Giagulli C.; Laudanna C.; Mafficini A.; Marcelli A.; Melotti P.; Piccinini M.; Sorio C. 2008

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