In and out blood-brain barrier endothelia (3B PASSPORT)

Starting date
April 15, 2009
Duration (months)
36
Managers or local contacts
Bentivoglio Marina , Constantin Gabriela , Fabene Paolo , Laudanna Carlo

The project will generate novel fundamental knowledge on how signalling within and between the different components of the blood-brain barrier (BBB) can regulate its permeability in health and disease and will investigate methods and their transport mechanisms to improve drug delivery through BBB endothelia into the brain parenchyma, including the identification of a new tool.
In this context, 3B PASSPORT has the following specific objectives:
A) To characterize endothelial signal transduction controlling BBB permeability
B) To investigate mechanisms of altered BBB permeability in neurological diseases

Sponsors:

7PQ VALUTATI POSITIVAMENTE
Funds: assigned and managed by the department
Syllabus: EUROPA - Progetti Europei

Project participants

Marina Bentivoglio
Full Professor
Gabriela Constantin
Full Professor
Paolo Fabene
Full Professor
Carlo Laudanna
Full Professor

Activities

Research facilities