Role of innate immune cells psoriasis

Starting date
January 1, 2013
Duration (months)
60
Managers or local contacts
Scapini Patrizia

Psoriasis is a common, chronic autoimmune skin disease, whose multifactorial pathogenesis is thought to result from a combination of genetic, environmental, and immunologic factors. Recent progress in the field has revealed that dysregulated interaction between immune cells (particularly T cells and DCs) and keratinocytes is crucial in driving inflammatory processes involved in the development and maintenance of the disease. By contrast, although innate immune cells, including neutrophils, monocytes, and macrophages, have also been shown to infiltrate the psoriatic plaques and to display abnormal functions in psoriatic patients, their role in disease pathogenesis has been poorly investigated. 
​This projecet has the aim to further investigate the specific role of neutrophils  and monocytes/macrophages in the Imiquimod (IMQ)-induced mouse model of psoriasis, as well as in psoriatic patients. 

Project participants

Patrizia Scapini
Associate Professor

Collaboratori esterni

MARCO A. CASSATELLA
UNIVERSITA' DI VERONA
GIAMPIERO GIROLOMONI
UNIVERSITA' DI VERONA
Publications
Title Authors Year
Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells. Costa, S; Marini, O; Bevilacqua, D; Defranco, Al; Hou, B; Lonardi, S; Vermi, W; Rodegher, P; Panato, A; Tagliaro, F; Lowell, Ca; Cassatella, Ma; Girolomoni, G; Scapini, P. 2017
Role of Neutrophils in an imiquimod induced mouse model of psoriasis. Bevilacqua, D.; Costa, S.; Cassatella, M.A.; Girolomoni, G.; Scapini, P. 2016

Activities

Research facilities