Ex vivo cellular models for skeletal diseases: evaluation of novel therapeutical approaches

Starting date
January 1, 2016
Duration (months)
36
Departments
Neurosciences, Biomedicine and Movement Sciences
Managers or local contacts
Dalle Carbonare Luca Giuseppe , Mottes Monica , Valenti Maria Teresa
Keyword
Osteogenesis; Osteoporosis; gene expression profiles; gene-supplements interactions

Post-menopausal osteoporosis and acromegaly are skeletal disorders involving in different ways the osteogenic lineage, as well as osteogenesis imperfecta (OI), a heterogeneous genetic disorder characterized by osteopenia and bone fragility. This project aims to 1) pharmacologically target signalling pathways involved in osteogenic maturation of progenitor stem cells and 2) tailor personalized treatments based on ex vivo approaches. A new formulation of bioactive supplements (vitamin D, ascorbic acid, fisetin, folic acid, pigment epithelium derived factor=PEDF) will be assayed on pluripotent stem cells (PSC) either from peripheral blood (circulating PSC) of osteoporotic and acromegalic patients or on fibroblast-derived stem cells of young OI patients (iPSC).

Sponsors:

Funds: assigned and managed by the department

Project participants

Samuele Cheri
Scholarship holder
Luca Giuseppe Dalle Carbonare
Associate Professor
Monica Mottes
Full Professor
Maria Teresa Valenti
Technical-administrative staff
Research areas involved in the project
Cell genetics

Activities

Research facilities