Molecular bases controlling the inflammatory reaction: mechanisms regulating neutrophil responsiveness to IL-10 and pathogenesis of neuronal damage by amyloidogenic proteins.

Starting date
November 26, 2001
Duration (months)
24
Managers or local contacts
Cassatella Marco Antonio
Keyword
NEUTROPHILS, MACROPHAGES/MICROGLIA, IL-10, LIPOPOLYSACCHARIDE, SOCS-3, CYTOKINES

The following projects continue lines of researches presented and cofinanced in occasion of previous applications (1997-1999; 1999-2001).
A) Line 1. Identification of the molecular mechanisms responsible of the modulatory effects of IL-10 on human neutrophils. A) Line 2. Role of SOCS-3 in mediating the biological effects of IL-10. A, line 3. Gene expression in professional phagocytes. B. The purpose of the investigation proposed in this project is to clarify the mechanisms of neuronal damage by amyloidogenic proteins.
B, line 1. Identification of the neuronal receptor interacting with Abeta and of the mechanisms the direct neuronal damage
2. Direct and inflammatory mechanisms of neuronal damage by prion proteins.

Sponsors:

Ministero dell'Istruzione dell'Università e della Ricerca
Funds: assigned and managed by the department
Syllabus: PRIN

Project participants

Flavia Bazzoni
Associate Professor
Federica Calzetti
Technical-administrative staff
Marco Antonio Cassatella
Full Professor

Activities

Research facilities