EMBRACING slanDC (2011-2013)

Starting date
June 1, 2011
Duration (months)
24
Managers or local contacts
Cassatella Marco Antonio
URL
http://ec.europa.eu/research/mariecurieactions/
Keyword
slanDC, Cytokines, apoptosis

objectives of this project are: (A) to identify the precise molecular bases that explain why IL-12p70 is produced at high levels by slanDC, and (B) how TLR signaling and IFNγ interact to regulate the survival of slanDC, which have never been explored to date. A further objective (C) that I plan to investigate relates to the expression of chemokines and chemokine receptors by slanDC (upon stimulation with TLR ligands) and how it differs from that of other DC subsets. In fact, slanDC infiltrate inflammatory sites where they frequently co-localize with other cell types, including polymorphonuclear neutrophil granulocytes. However, the mechanisms regulating the recruitment of slanDC are obscure as well as their potential to induce the migration of other cell types.

Sponsors:

Commissione europea – VII PQ
Funds: assigned and managed by the department

Project participants

Activities

Research facilities