Role of innate immune cells psoriasis

Data inizio
1 gennaio 2013
Durata (mesi) 
60
Responsabili (o referenti locali)
Scapini Patrizia

Psoriasis is a common, chronic autoimmune skin disease, whose multifactorial pathogenesis is thought to result from a combination of genetic, environmental, and immunologic factors. Recent progress in the field has revealed that dysregulated interaction between immune cells (particularly T cells and DCs) and keratinocytes is crucial in driving inflammatory processes involved in the development and maintenance of the disease. By contrast, although innate immune cells, including neutrophils, monocytes, and macrophages, have also been shown to infiltrate the psoriatic plaques and to display abnormal functions in psoriatic patients, their role in disease pathogenesis has been poorly investigated. 
​This projecet has the aim to further investigate the specific role of neutrophils  and monocytes/macrophages in the Imiquimod (IMQ)-induced mouse model of psoriasis, as well as in psoriatic patients. 

Partecipanti al progetto

Patrizia Scapini
Professore associato

Collaboratori esterni

MARCO A. CASSATELLA
UNIVERSITA' DI VERONA
GIAMPIERO GIROLOMONI
UNIVERSITA' DI VERONA
Pubblicazioni
Titolo Autori Anno
Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells. Costa, S; Marini, O; Bevilacqua, D; Defranco, Al; Hou, B; Lonardi, S; Vermi, W; Rodegher, P; Panato, A; Tagliaro, F; Lowell, Ca; Cassatella, Ma; Girolomoni, G; Scapini, P. 2017
Role of Neutrophils in an imiquimod induced mouse model of psoriasis. Bevilacqua, D.; Costa, S.; Cassatella, M.A.; Girolomoni, G.; Scapini, P. 2016

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