Pubblicazioni

Autori:

Cavaliere, Alessandro; Merz, Valeria; Casalino, Simona; Zecchetto, Camilla; Simionato, Francesca; Salt, Hayley Louise; Contarelli, Serena; Santoro, Raffaela; Melisi, Davide

Titolo:

Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer

Anno:

2019

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

JOURNAL OF GASTRIC CANCER

ISSN Rivista:

2093-582X

N° Volume:

19

Numero o Fascicolo:

4

Intervallo pagine:

375-392

Parole chiave:

Baculoviral IAP repeat-containing 3 protein; Gastric cancer; HOXB9 protein, human; Microsatellite instability; Receptor, fibroblast growth factor, type 3

Breve descrizione dei contenuti:

Preoperative chemo- and radiotherapeutic strategies followed by surgery are currently a standard approach for treating locally advanced gastric and esophagogastric junction cancer in Western countries. However, in a large number of cases, the tumor is extremely resistant to these treatments and the patients are exposed to unnecessary toxicity and delayed surgical therapy. The current clinical trials evaluating the combination of preoperative systemic therapies with modern targeted and immunotherapeutic agents represent a unique opportunity for identifying predictive biomarkers of response to select patients that would benefit the most from these treatments. However, it is of utmost importance that these potential biomarkers are corroborated by extensive preclinical and translational research. The aim of this review article is to present the most promising biomarkers of response to classic chemotherapeutic, anti-HER2, antiangiogenic, and immunotherapeutic agents that can be potentially useful for personalized preoperative systemic therapies in gastric cancer patients.

Id prodotto:

113550

Handle IRIS:

11562/1014050

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Cavaliere, Alessandro; Merz, Valeria; Casalino, Simona; Zecchetto, Camilla; Simionato, Francesca; Salt, Hayley Louise; Contarelli, Serena; Santoro, Raffaela; Melisi, Davide, Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer «JOURNAL OF GASTRIC CANCER» , vol. 19 , n. 4 , 2019 , pp. 375-392

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