Pubblicazioni

Autori:

De Vincentis, Antonio; Vespasiani-Gentilucci, Umberto; Costanzo, Luisa; Novella, Alessio; Cortesi, Laura; Nobili, Alessandro; Mannucci, Pier Mannuccio; Incalzi, Raffaele Antonelli; Minuz, Pietro; Fondrieschi, Luigi; Morellini, Sarah

Titolo:

The multifaceted spectrum of liver cirrhosis in older hospitalised patients: analysis of the REPOSI registry

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Age and Ageing

ISSN Rivista:

0002-0729

N° Volume:

50

Numero o Fascicolo:

2

Intervallo pagine:

498-504

Parole chiave:

disability; hospitalisation; liver cirrhosis; mortality; older people; phenotypes; Aged; Hospital Mortality; Hospitalization; Humans; Liver Cirrhosis; Registries; Aftercare; Patient Discharge

Breve descrizione dei contenuti:

Background: Knowledge on the main clinical and prognostic characteristics of older multimorbid subjects with liver cirrhosis (LC) admitted to acute medical wards is scarce.Objectives: To estimate the prevalence of LC among older patients admitted to acute medical wards and to assess the main clinical characteristics of LC along with its association with major clinical outcomes and to explore the possibility that well-distinguished phenotypic profiles of LC have classificatory and prognostic properties.Methods: A cohort of 6,193 older subjects hospitalised between 2010 and 2018 and included in the REPOSI registry was analysed.Results: LC was diagnosed in 315 patients (5%). LC was associated with rehospitalisation (age-sex adjusted hazard ratio, [aHR] 1.44; 95% CI, 1.10-1.88) and with mortality after discharge, independently of all confounders (multiple aHR, 2.1; 95% CI, 1.37-3.22), but not with in-hospital mortality and incident disability. Threemain clinical phenotypes of LC patients were recognised: relatively fit subjects (FIT, N = 150), subjects characterised by poor social support (PSS, N = 89) and, finally, subjects with disability and multimorbidity (D&M, N = 76). PSS subjects had an increased incident disability (35% vs 13%, P < 0.05) compared to FIT. D&M patients had a higher mortality (in-hospital: 12% vs 3%/1%, P < 0.01; post-discharge: 41% vs 12%/15%, P < 0.01) and less rehospitalisation (10% vs 32%/34%, P < 0.01) compared to PSS and FIT.Conclusions: LC has a relatively low prevalence in older hospitalised subjects but, when present, accounts for worse postdischarge outcomes. Phenotypic analysis unravelled the heterogeneity of LC older population and the association of selected phenotypes with different clinical and prognostic features.

Id prodotto:

127713

Handle IRIS:

11562/1063681

ultima modifica:

9 aprile 2023

Citazione bibliografica:

De Vincentis, Antonio; Vespasiani-Gentilucci, Umberto; Costanzo, Luisa; Novella, Alessio; Cortesi, Laura; Nobili, Alessandro; Mannucci, Pier Mannuccio; Incalzi, Raffaele Antonelli; Minuz, Pietro; Fondrieschi, Luigi; Morellini, Sarah, The multifaceted spectrum of liver cirrhosis in older hospitalised patients: analysis of the REPOSI registry «Age and Ageing» , vol. 50 , n. 2 , 2021 , pp. 498-504

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo