Pubblicazioni

Autori:

Caminati, Marco; Maule, Matteo; Bello, Federica; Emmi, Giacomo

Titolo:

Biologics for eosinophilic granulomatosis with polyangiitis

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY

ISSN Rivista:

1528-4050

N° Volume:

23

Numero o Fascicolo:

1

Intervallo pagine:

36-43

Parole chiave:

EGPA Biologics

Breve descrizione dei contenuti:

Purpose of review: The link between severe asthma and eosinophilic granulomatosis with polyangiitis (EGPA) in terms of pathophysiological background, clinical manifestations and disease evolution has leaded to investigate the relevance of anti T2 monoclonal antibodies licensed for severe asthma patients as a treatment option for EGPA. The present review aimed to provide un update on EGPA pathophysiology and to critically summarize the most robust evidence coming from trials and real-life setting on the use of anti T2 biologics in EGPA patients. Recent findings: Mepolizumab, an anti-interleukin-5 monoclonal antibody, is the only biologic drug targeting eosinophilic inflammation currently approved for EGPA treatment at the dose of 300 mg/4 weeks. Its use is restricted by the American College of Rheumatology guidelines to specific diseases phases and severity grades. However the most appropriate mepolizumab positioning and dose is still under investigation in the real life practice, which is providing an increasing amount of evidence confirming its efficacy, alone or in combination with other options in different disease stages. The relevance of other monoclonal antibodies interfering with T2 inflammation, including omalizumab and benralizumab, is under investigation but the evidence is still scarce. Summary: Taking into account the suboptimal medium-long term safety profile of conventional EGPA treatments, the opportunity of selectively targeting eosinophilic inflammation certainly represents a revolutionary approach. However, further real-word evidence is required to effectively position the new treatments in the light of the disease complexity, including different immunological drivers, and individual variability.

Id prodotto:

131387

Handle IRIS:

11562/1083598

ultima modifica:

23 febbraio 2023

Citazione bibliografica:

Caminati, Marco; Maule, Matteo; Bello, Federica; Emmi, Giacomo, Biologics for eosinophilic granulomatosis with polyangiitis «CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY» , vol. 23 , n. 1 , 2023 , pp. 36-43

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