Pubblicazioni

Autori:

Gargiulo, Luigi; Ibba, Luciano; Malagoli, Piergiorgio; Amoruso, Fabrizio; Argenziano, Giuseppe; Balato, Anna; Bardazzi, Federico; Burlando, Martina; Giovanni Carrera, Carlo; Damiani, Giovanni; Dapavo, Paolo; Dini, Valentina; Franchi, Chiara; Maria Gaiani, Francesca; Girolomoni, Giampiero; Guarneri, Claudio; Lasagni, Claudia; Loconsole, Francesco; Valerio Marzano, Angelo; Maurelli, Martina; Megna, Matteo; Orsini, Diego; Sampogna, Francesca; Travaglini, Massimo; Valenti, Mario; Costanzo, Antonio; Narcisi, Alessandra

Titolo:

Effectiveness, Tolerability, and Drug Survival of Risankizumab in a Real-World Setting: A Three-Year Retrospective Multicenter Study—IL PSO (ITALIAN LANDSCAPE PSORIASIS)

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

JOURNAL OF CLINICAL MEDICINE

ISSN Rivista:

2240-0109

Intervallo pagine:

1-13

Parole chiave:

psoriasis; risankizumab; real-world evidence; biological therapy

Breve descrizione dei contenuti:

Background: Risankizumab is a humanized monoclonal antibody that selectively inhibits interleukin-23. It has been approved for moderate-to-severe plaque psoriasis and has shown efficacy and safety in clinical trials and real-world experiences. This study aimed to evaluate the long-term effectiveness, safety, and drug survival of risankizumab in a real-life setting. Materials and Methods: We included patients treated with risankizumab from January 2019 to February 2023. A Psoriasis Area and Severity Index score (PASI) was collected at weeks 0, 16, 28, 52, 104, and 156, when available. The occurrence of any adverse events was recorded at each visit. Results: We enrolled 1047 patients. At week 52, a ≥90% improvement in PASI was observed in 81.44% of patients, with a continuous improvement throughout the study (88.99% and 99.07% at weeks 104 and 156, respectively). After three years of treatment, all patients involving the scalp, palms/soles, and genitalia and 95% of patients with nail psoriasis achieved a complete or almost complete skin clearance. No significant safety findings were observed, and 90.73% of the patients were still on treatment after 36 months. Conclusions: This study supports the long-term effectiveness and safety of risankizumab in a real- world setting, even in patients involving difficult-to-treat areas.

Id prodotto:

137237

Handle IRIS:

11562/1117406

ultima modifica:

31 ottobre 2024

Citazione bibliografica:

Gargiulo, Luigi; Ibba, Luciano; Malagoli, Piergiorgio; Amoruso, Fabrizio; Argenziano, Giuseppe; Balato, Anna; Bardazzi, Federico; Burlando, Martina; Giovanni Carrera, Carlo; Damiani, Giovanni; Dapavo, Paolo; Dini, Valentina; Franchi, Chiara; Maria Gaiani, Francesca; Girolomoni, Giampiero; Guarneri, Claudio; Lasagni, Claudia; Loconsole, Francesco; Valerio Marzano, Angelo; Maurelli, Martina; Megna, Matteo; Orsini, Diego; Sampogna, Francesca; Travaglini, Massimo; Valenti, Mario; Costanzo, Antonio; Narcisi, Alessandra, Effectiveness, Tolerability, and Drug Survival of Risankizumab in a Real-World Setting: A Three-Year Retrospective Multicenter Study—IL PSO (ITALIAN LANDSCAPE PSORIASIS) «JOURNAL OF CLINICAL MEDICINE» , 2024 , pp. 1-13

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