Pubblicazioni

Autori:

Carletto A; Pacor ML; Biasi D; Caramaschi P; Zeminian S; Bellavite P; Bambara LM

Titolo:

Changes of neutrophil migration without modification of in vitro metabolism and adhesion in Behcet's disease

Anno:

1997

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Rheumatology

ISSN Rivista:

0315-162X

N° Volume:

24

Numero o Fascicolo:

7

Intervallo pagine:

1332-1336

Codice PMID:

9228133

Parole chiave:

Behcet's disease (BD), neutrophil function, chemotaxis

Breve descrizione dei contenuti:

Objective. Increase of neutrophil chemotaxis in Behcet's disease (BD) has been described, but it is not clear whether there is a correlation with other variables of neutrophil function and whether these modifications correlate with disease activity. Methods. We studied neutrophil functions in patients with BD in the acute phase in comparison with healthy control subjects and with the same patients during disease remission, with or without therapy. We investigated in vivo neutrophil migration by Senn's skin window technique and measured adhesion assay and superoxide production in circulating and migrating neutrophils after different stimuli. Results. Neutrophil migration in vivo was 101.3 +- 17.9 times 10-6 polymorphonuclear lymphocytes (PMN)/cm-2/24 h in patients with BD in the acute phase and 66.1 +- 7.8 times 10-6 PMN/cm-2/24 h in controls (p lt 0.001). No correlation was found between leukocyte counts and neutrophil migration. Neutrophil migration evaluated in the same patients in a phase of disease remission was 58.3 +- 10.3 times 10-6 PMN/cm-2/24 h (p lt 0.001 vs acute phase, not significant vs controls). The neutrophils of the exudate were normally primed to response to the chemotactic peptide fMLP. No differences between the 2 groups were found in superoxide production, adhesion under basal conditions, or in response to different stimuli by circulating and migrating neutrophils. Conclusion. Abnormally high migration of neutrophils in the active phase of BD is the only consistent neutrophil dysfunction. Since this modification is reversed by therapy, the evaluation of in vivo neutrophil migration may be useful in diagnosing and monitoring disease activity. Blood neutrophils have normal responses to different stimuli, indicating they are not primed by the disease state.

Id prodotto:

1126

Handle IRIS:

11562/1126

ultima modifica:

2 novembre 2016

Citazione bibliografica:

Carletto A; Pacor ML; Biasi D; Caramaschi P; Zeminian S; Bellavite P; Bambara LM, Changes of neutrophil migration without modification of in vitro metabolism and adhesion in Behcet's disease «Journal of Rheumatology» , vol. 24 , n. 7 , 1997 , pp. 1332-1336

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