Pubblicazioni

Autori:

Pini, Laura; Bagnasco, Diego; Beghè, Bianca; Braido, Fulvio; Cameli, Paolo; Caminati, Marco; Caruso, Cristiano; Crimi, Claudia; Guarnieri, Gabriella; Latorre, Manuela; Menzella, Francesco; Micheletto, Claudio; Vianello, Andrea; Visca, Dina; Bondi, Benedetta; El Masri, Yehia; Giordani, Jordan; Mastrototaro, Andrea; Maule, Matteo; Pini, Alessandro; Piras, Stefano; Zappa, Martina; Senna, Gianenrico; Spanevello, Antonio; Paggiaro, Pierluigi; Blasi, Francesco; Canonica, Giorgio Walter; Null, Null

Titolo:

Unlocking the Long-Term Effectiveness of Benralizumab in Severe Eosinophilic Asthma: A Three-Year Real-Life Study

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

JOURNAL OF CLINICAL MEDICINE

ISSN Rivista:

2077-0383

N° Volume:

13

Numero o Fascicolo:

10

Intervallo pagine:

1-15

Parole chiave:

benralizumab; clinical remission; effectiveness; long term; severe eosinophilic asthma

Breve descrizione dei contenuti:

Background: Benralizumab has been shown to restore good control of severe eosinophilic asthma (SEA). Robust data on benralizumab effectiveness over periods longer than 2 years are scarce. Methods: This retrospective multicentric study was conducted on 108 Italian SEA patients treated with benralizumab for up to 36 months. Partial and complete clinical remission (CR) were assessed. Data were analyzed with descriptive statistics or using linear, logistic, and negative binomial mixed-effect regression models. Results: At 36 months, benralizumab reduced the exacerbation rate by 89% and increased the forced expiratory volume in 1 second (FEV1) (+440 mL at 36 months, p < 0.0001). Benralizumab improved asthma control as well as sinonasal symptoms in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). Up to 93.33% of patients either reduced or discontinued OCS; benralizumab also decreased ICS use and other asthma medications. Overall, 84.31% of patients achieved partial or complete CR. Conclusions: Benralizumab improved asthma and sinonasal outcomes up to 36 months. These findings support the potential of benralizumab to induce CR, emphasizing its role as a disease-modifying anti-asthmatic drug for the management of SEA. Further research is warranted to expand these findings by minimizing data loss and assessing benralizumab's long-term safety.

Id prodotto:

144440

Handle IRIS:

11562/1155690

ultima modifica:

24 maggio 2025

Citazione bibliografica:

Pini, Laura; Bagnasco, Diego; Beghè, Bianca; Braido, Fulvio; Cameli, Paolo; Caminati, Marco; Caruso, Cristiano; Crimi, Claudia; Guarnieri, Gabriella; Latorre, Manuela; Menzella, Francesco; Micheletto, Claudio; Vianello, Andrea; Visca, Dina; Bondi, Benedetta; El Masri, Yehia; Giordani, Jordan; Mastrototaro, Andrea; Maule, Matteo; Pini, Alessandro; Piras, Stefano; Zappa, Martina; Senna, Gianenrico; Spanevello, Antonio; Paggiaro, Pierluigi; Blasi, Francesco; Canonica, Giorgio Walter; Null, Null, Unlocking the Long-Term Effectiveness of Benralizumab in Severe Eosinophilic Asthma: A Three-Year Real-Life Study «JOURNAL OF CLINICAL MEDICINE» , vol. 13 , n. 10 , 2024 , pp. 1-15

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo