Pubblicazioni

Autori:

Caminati, Marco; Maule, Matteo; Benoni, Roberto; Bagnasco, Diego; Beghè, Bianca; Braido, Fulvio; Brussino, Luisa; Cameli, Paolo; Candeliere, Maria Giulia; Carpagnano, Giovanna Elisiana; Costanzo, Giulia; Crimi, Claudia; D'Amato, Mariella; Del Giacco, Stefano; Guarnieri, Gabriella; Yacoub, Mona-Rita; Micheletto, Claudio; Nicola, Stefania; Olivieri, Bianca; Pini, Laura; Schiappoli, Michele; Vaia, Rachele; Vianello, Andrea; Visca, Dina; Spanevello, Antonio; Senna, Gianenrico

Titolo:

Dupilumab Efficacy on Asthma Functional, Inflammatory, and Patient-Reported Outcomes across Different Disease Phenotypes and Severity: A Real-Life Perspective

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

BIOMEDICINES

ISSN Rivista:

2227-9059

N° Volume:

12

Numero o Fascicolo:

2

Intervallo pagine:

2-10

Parole chiave:

asthma; biologics; chronic rhinosinusitis with nasal polyps; dupilumab; lung function; real-life

Breve descrizione dei contenuti:

Dupilumab is currently approved for the treatment of Type 2 severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Few studies have specifically reported on dupilumab efficacy on asthma outcomes as a primary objective in a real-life setting, in patients with and without CRSwNP. Our study aimed to explore the efficacy of dupilumab on functional, inflammatory, and patient-reported outcomes in asthma patients across different disease phenotypes and severity, including mild-to-moderate asthma coexisting with CRSwNP. Data from 3, 6, and 12 months follow-up were analyzed. Asthma (FEV1%, Tiffeneau%, ACT, FeNO, oral steroid use, exacerbation rate, and blood eosinophilia) and polyposis (SNOT22, VAS, NPS) outcomes showed a rapid (3 months) and sustained (6 and 12 months) significant change from baseline, despite most of the patients achieving oral steroid withdrawal. According to the sensitivity analysis, the improvement was not conditioned by either the presence of polyposis or severity of asthma at baseline. Of note, even in the case of milder asthma forms, a significant further improvement was recorded during dupilumab treatment course. Our report provides short-, medium-, and long-term follow-up data on asthma outcomes across different diseases phenotypes and severity, contributing to the real-world evidence related to dupilumab efficacy on upper and lower airways T2 inflammation.

Id prodotto:

144431

Handle IRIS:

11562/1155729

ultima modifica:

1 maggio 2025

Citazione bibliografica:

Caminati, Marco; Maule, Matteo; Benoni, Roberto; Bagnasco, Diego; Beghè, Bianca; Braido, Fulvio; Brussino, Luisa; Cameli, Paolo; Candeliere, Maria Giulia; Carpagnano, Giovanna Elisiana; Costanzo, Giulia; Crimi, Claudia; D'Amato, Mariella; Del Giacco, Stefano; Guarnieri, Gabriella; Yacoub, Mona-Rita; Micheletto, Claudio; Nicola, Stefania; Olivieri, Bianca; Pini, Laura; Schiappoli, Michele; Vaia, Rachele; Vianello, Andrea; Visca, Dina; Spanevello, Antonio; Senna, Gianenrico, Dupilumab Efficacy on Asthma Functional, Inflammatory, and Patient-Reported Outcomes across Different Disease Phenotypes and Severity: A Real-Life Perspective «BIOMEDICINES» , vol. 12 , n. 2 , 2024 , pp. 2-10

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo