Serum selenium in liver cirrhosis: correlation with markers of fibrosis
Anno:
1989
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Referee:
Sì
Nome rivista:
Clinica Chimica Acta
ISSN Rivista:
0009-8981
N° Volume:
182
Intervallo pagine:
221-7
Breve descrizione dei contenuti:
In 55 patients with alcoholic cirrhosis and in 47 healthy individuals we assayed the concentration of selenium in serum (S-Se) by proton induced X-ray emission, the aminoterminal peptide of type III procollagen (NPIIIP) by RIA and the plasma fibronectin (FN) by immuno-nephelometry, together with routine biochemical tests. S-Se was lower in cirrhosis than in controls (0.57, SD 0.20 vs 0.92, SD 0.16 mumol/l; p less than 0.001) and was more reduced in ascitic than in compensated patients (0.50, SD 0.19 vs 0.66, SD 0.17 mumol/l; p less than 0.001). Regression analysis showed a positive correlation of S-Se with serum albumin and FN, whereas necrotic or inflammatory activity seems unrelated to S-Se; a negative correlation was found between S-Se and NPIIIP, suggesting a protective role of selenium against fibrosis.
Id prodotto:
1871
Handle IRIS:
11562/1871
depositato il:
8 agosto 2007
ultima modifica:
3 novembre 2022
Citazione bibliografica:
Casaril, Massimo; Stanzial, Annamaria; Gabrielli, G. B.; Capra, Franco; Zenari, L.; Galassini, Silvio; Moschini, G.; Liu, N. Q.; Corrocher, Roberto,
Serum selenium in liver cirrhosis: correlation with markers of fibrosis«Clinica Chimica Acta»
, vol. 182
, 1989
, pp. 221-7