Pubblicazioni

Autori:

A. M. Stanzial; L. Bonomi; C. Cobbe; O. Olivieri; D. Girelli; M. T. Trevisan; A. Bassi; S. Ferrari; R. Corrocher

Titolo:

Erythrocyte and platelet fatty acids in retinitis pigmentosa

Anno:

1991

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Nazioni degli autori:

ITALIA

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Endocrinological Investigation

ISSN Rivista:

0391-4097

N° Volume:

14

Intervallo pagine:

295-302

Breve descrizione dei contenuti:

The fatty acid composition and the glutathione-peroxidase activity (GSH-Px) of erythrocytes and platelets, the production of malondialdehyde (MDA) by platelets and the activity of the main systems of transmembrane cation transport in erythrocyte have been studied in 12 patients (5 males and 7 females) affected by retinitis pigmentosa (RP). A remarkable increase of saturated fatty acids (SFA), particularly of stearic acid (C18:0), has been noted in these patients. The reduced unsaturated/saturated fatty acids ratio (PUFA/SFA) observed in both erythrocytes and platelets and the decrease of arachidonic acid in platelets may depend by an active peroxidation process as documented by the increase of MDA. Platelet glutathione-peroxidase (PTL-GSH-PX) and plasma retinol were in the normal range, whereas erythrocyte glutathione-peroxidase (E-GSH-PX), MDA and plasma alfa-toco-pherol were increased in patients with RP. The activities of Na(+)-K+ pump, cotransport and Na(+)-Li+ countertransport were normal in RP erythrocytes.

Id prodotto:

2390

Handle IRIS:

11562/2390

depositato il:

2 agosto 2007

ultima modifica:

2 novembre 2016

Citazione bibliografica:

A. M. Stanzial; L. Bonomi; C. Cobbe; O. Olivieri; D. Girelli; M. T. Trevisan; A. Bassi; S. Ferrari; R. Corrocher, Erythrocyte and platelet fatty acids in retinitis pigmentosa «Journal of Endocrinological Investigation» , vol. 14 , 1991 , pp. 295-302

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