Pubblicazioni

Autori:

R. Corrocher; L. Guadagnin; M. De Gironcoli; D. Girelli; P. Guarini; O. Olivieri; S. Caffi; A. M. Stanzial; S. Ferrari; L. Grigolini

Titolo:

Membrane fatty acids, glutathione-peroxidase activity, and cation transport systems of erythrocytes and malondialdehyde production by platelets in Laurence Moon Barter Biedl syndrome

Anno:

1989

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Nazioni degli autori:

ITALIA

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Endocrinological Investigation

ISSN Rivista:

0391-4097

N° Volume:

12

Intervallo pagine:

475-481

Breve descrizione dei contenuti:

The fatty acid composition of erythrocyte membrane, the glutathione-peroxidase activity of erythrocytes and platelets, the production of malondialdehyde by platelets and the activity of the main systems of transmembrane cation transport have been studied in 5 members of a family, 2 of whom affected by Laurence-Moon-Barter-Biedl Syndrome. A remarkable increase of polyunsaturated fatty acids (particularly arachidonic acid) and of cholesterol/phospholipid molar ratio has been noted. This pattern of membrane lipids was associated to an increment of malondialdehyde production and an increase activity of glutathione-peroxidase. Serum retinol and a-tocopherol were in the normal range, whereas serum selenium was low in 3 out of 5 members. Moreover, the alteration of membrane lipids was associated to a decrease of the maximal velocity of Li-Na countertransport. We speculate that the enrichment of polyunsaturated fatty acids on the cell membranes may represent a condition favoring the lipoperoxidation and therefore the development of the retinitis pigmentosa characteristic feature of Laurence-Moon-Barter-Biedl Syndrome.

Id prodotto:

2395

Handle IRIS:

11562/2395

depositato il:

7 luglio 2007

ultima modifica:

2 novembre 2016

Citazione bibliografica:

R. Corrocher; L. Guadagnin; M. De Gironcoli; D. Girelli; P. Guarini; O. Olivieri; S. Caffi; A. M. Stanzial; S. Ferrari; L. Grigolini, Membrane fatty acids, glutathione-peroxidase activity, and cation transport systems of erythrocytes and malondialdehyde production by platelets in Laurence Moon Barter Biedl syndrome «Journal of Endocrinological Investigation» , vol. 12 , 1989 , pp. 475-481

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