Publications

Multiple roles of Lyn kinase in myeloid cell signaling and function.  (2009)

Authors:
Scapini P.; Pereira S.; Zhang H.; Lowell CA.
Title:
Multiple roles of Lyn kinase in myeloid cell signaling and function.
Year:
2009
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Nations of authors:
STATI UNITI D'AMERICA; ITALIA
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
Immunology Review
ISSN of journal:
0105-2896
N° Volume:
228
Number or Folder:
1
Page numbers:
23-40
Code PMID:
19290919
Keyword:
Inflammation, Kinase, Lyn, Myeloid cells, Myeloproliferation
Short description of contents:
Lyn is an Src family kinase present in B lymphocytes and myeloid cells. In these cell types, Lyn establishes signaling thresholds by acting as both a positive and a negative modulator of a variety of signaling responses and effector functions. Lyn deficiency in mice results in the development of myeloproliferation and autoimmunity. The latter has been attributed to the hyper-reactivity of Lyn-deficient B cells due to the unique role of Lyn in downmodulating B-cell receptor activation, mainly through phosphorylation of inhibitory molecules and receptors. Myeloproliferation results, on the other hand, from the enhanced sensitivity of Lyn-deficient progenitors to a number of colony-stimulating factors (CSFs). The hyper-sensitivity to myeloid growth factors may also be secondary to poor inhibitory receptor phosphorylation, leading to impaired recruitment/activation of tyrosine phosphatases and reduced downmodulation of CSF signaling responses. Despite these observations, the overall role of Lyn in the modulation of myeloid cell effector functions is much less well understood, as often both positive and negative roles of this kinase have been reported. In this review, we discuss the current knowledge of the duplicitous nature of Lyn in the modulation of myeloid cell signaling and function.
Product ID:
48752
Handle IRIS:
11562/327348
Deposited On:
October 26, 2016
Last Modified:
November 2, 2016
Bibliographic citation:
Scapini P.; Pereira S.; Zhang H.; Lowell CA., Multiple roles of Lyn kinase in myeloid cell signaling and function. «Immunology Review» , vol. 228 , n. 12009pp. 23-40

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

Related projects
Title Department Managers
<<back

Activities

Research facilities