Publications

Authors:

Scapini, Patrizia; Pereira, S.; Zhang, H.; Lowell, C. A.

Title:

Multiple roles of Lyn kinase in myeloid cell signaling and function.

Year:

2009

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Immunology Review

ISSN of journal:

0105-2896

N° Volume:

228

Number or Folder:

1

Page numbers:

23-40

Keyword:

Inflammation; Kinase; Lyn; Myeloid cells; Myeloproliferation

Short description of contents:

Lyn is an Src family kinase present in B lymphocytes and myeloid cells. In these cell types, Lyn establishes signaling thresholds by acting as both a positive and a negative modulator of a variety of signaling responses and effector functions. Lyn deficiency in mice results in the development of myeloproliferation and autoimmunity. The latter has been attributed to the hyper-reactivity of Lyn-deficient B cells due to the unique role of Lyn in downmodulating B-cell receptor activation, mainly through phosphorylation of inhibitory molecules and receptors. Myeloproliferation results, on the other hand, from the enhanced sensitivity of Lyn-deficient progenitors to a number of colony-stimulating factors (CSFs). The hyper-sensitivity to myeloid growth factors may also be secondary to poor inhibitory receptor phosphorylation, leading to impaired recruitment/activation of tyrosine phosphatases and reduced downmodulation of CSF signaling responses. Despite these observations, the overall role of Lyn in the modulation of myeloid cell effector functions is much less well understood, as often both positive and negative roles of this kinase have been reported. In this review, we discuss the current knowledge of the duplicitous nature of Lyn in the modulation of myeloid cell signaling and function.

Product ID:

48752

Handle IRIS:

11562/327348

Deposited On:

March 27, 2012

Last Modified:

November 15, 2022

Bibliographic citation:

Scapini, Patrizia; Pereira, S.; Zhang, H.; Lowell, C. A., Multiple roles of Lyn kinase in myeloid cell signaling and function. «Immunology Review» , vol. 228 , n. 1 , 2009 , pp. 23-40

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