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The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity  (2010)

Authors:
Tavares RM; Turer EE; Liu CL; Advincula R; Scapini P; Rhee L; Barrera J; Lowell CA; Utz PJ; Malynn BA; Ma A
Title:
The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity
Year:
2010
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
Immunity
ISSN of journal:
1074-7613
N° Volume:
33
Number or Folder:
2
Page numbers:
181-191
Code PMID:
20705491
Keyword:
MOLIMMUNO, CELLIMMUNO, SIGNALING
Short description of contents:
A20 is a ubiquitin modifying enzyme that restricts NF-kappaB signals and protects cells against tumor necrosis factor (TNF)-induced programmed cell death. Given recent data linking A20 (TNFAIP3) with human B cell lymphomas and systemic lupus erythematosus (SLE), we have generated mice bearing a floxed allele of Tnfaip3 to interrogate A20's roles in regulating B cell functions. A20-deficient B cells are hyperresponsive to multiple stimuli and display exaggerated NF-kappaB responses to CD40-induced signals. Mice expressing absent or hypomorphic amounts of A20 in B cells possess elevated numbers of germinal center B cells, autoantibodies, and glomerular immunoglobulin deposits. A20-deficient B cells are resistant to Fas-mediated cell death, probably due to increased expression of NF-kappaB-dependent antiapoptotic proteins such as Bcl-x. These findings show that A20 can restrict B cell survival, whereas A20 protects other cells from TNF-induced cell death. Our studies demonstrate how reduced A20 expression predisposes to autoimmunity.
Product ID:
57607
Handle IRIS:
11562/345450
Deposited On:
November 4, 2016
Last Modified:
November 23, 2016
Bibliographic citation:
Tavares RM; Turer EE; Liu CL; Advincula R; Scapini P; Rhee L; Barrera J; Lowell CA; Utz PJ; Malynn BA; Ma A, The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity «Immunity» , vol. 33 , n. 22010pp. 181-191

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