Publications

Authors:

Carbone, C.; Melisi, Davide

Title:

NF-κB as a target for pancreatic cancer therapy.

Year:

2012

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

EXPERT OPINION ON THERAPEUTIC TARGETS

ISSN of journal:

1472-8222

Page numbers:

1-10

Keyword:

NFkB; TAK1

Short description of contents:

Introduction: Pancreatic cancer is the fourth leading cause of adult cancer mortality in the USA. It represents one of the greatest challenges in cancer treatment. The NF-κB transcriptional factors are constitutively activated in the majority of pancreatic cancers and are involved in the regulation of numerous aspects of tumor development and progression. NF-κB and the signaling cascades that regulate its activity have thus become attractive targets for novel therapeutic approaches for pancreatic cancer. Areas covered: This review describes and discusses the most important advances in the comprehension of the complex molecular biology of NF-κB, as well as the development of novel NF-κB-targeting strategies for the treatment of pancreatic cancer. Expert opinion: Although the inhibition of NF-κB, especially when combined with more classic chemotherapeutic drugs, could be a promising therapeutic strategy, direct targeting NF-κB still faces important challenges. In the future, targeting nonredundant cytosolic mediators of the activation of NF-κB - such as TNF receptor associated factor family member-associated NF-κB activator -binding kinase 1 (TBK1) and TGF-beta activated kinase 1 (TAK1) - could represent a better approach to inhibit key processes in pancreatic tumor cells and make a difference for this devastating disease.

Web page:

http://dx.doi.org/10.1517/14728222.2011.645806

Product ID:

66728

Handle IRIS:

11562/393944

Deposited On:

March 27, 2012

Last Modified:

November 15, 2022

Bibliographic citation:

Carbone, C.; Melisi, Davide, NF-κB as a target for pancreatic cancer therapy. «EXPERT OPINION ON THERAPEUTIC TARGETS» , 2012 , pp. 1-10

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