Publications

Social networking of human neutrophils within the immune system  (2014)

Authors:
Scapini P;Cassatella MA
Title:
Social networking of human neutrophils within the immune system
Year:
2014
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Nations of authors:
ITALIA
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
Blood
ISSN of journal:
0006-4971
N° Volume:
124
Number or Folder:
5
:
American Society of Hematology
Page numbers:
710-719
Code PMID:
24923297
Keyword:
neutrophils, neutrophil biology, neutrophil heterogeneity, neutrophil plasticity
Short description of contents:
It is now widely recognized that neutrophils are highly versatile and sophisticated cells that display de novo synthetic capacity and may greatly extend their lifespan. In addition, concepts such as "neutrophil heterogeneity" and "neutrophil plasticity" have started to emerge, implying that, under pathological conditions, neutrophils may differentiate into discrete subsets defined by distinct phenotypic and functional profiles. A number of studies have shown that neutrophils act as effectors in both innate and adaptive immunoregulatory networks. In fact, once recruited into inflamed tissues, neutrophils engage into complex bidirectional interactions with macrophages, natural killer, dendritic and mesenchymal stem cells, B and T lymphocytes or platelets. As a result of this crosstalk, mediated either by contact-dependent mechanisms or cell-derived soluble factors, neutrophils and target cells reciprocally modulate their survival and activation status. Altogether, these novel aspects of neutrophil biology have shed a new light not only on the potential complex roles that neutrophils play during inflammation and immune responses, but also in the pathogenesis of several inflammatory disorders including infection, autoimmunity and cancer.
Note:
pii: blood-2014-03-453217
Product ID:
82143
Handle IRIS:
11562/750165
Deposited On:
October 25, 2016
Last Modified:
November 2, 2016
Bibliographic citation:
Scapini P;Cassatella MA, Social networking of human neutrophils within the immune system «Blood» , vol. 124 , n. 52014pp. 710-719

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