Publications

Authors:

Scapini, Patrizia; Cassatella, Marco Antonio

Title:

Social networking of human neutrophils within the immune system

Year:

2014

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

Blood

ISSN of journal:

0006-4971

N° Volume:

124

Number or Folder:

5

:

American Society of Hematology

Page numbers:

710-719

Keyword:

neutrophils; neutrophil biology; neutrophil heterogeneity; neutrophil plasticity

Short description of contents:

It is now widely recognized that neutrophils are highly versatile and sophisticated cells that display de novo synthetic capacity and may greatly extend their lifespan. In addition, concepts such as "neutrophil heterogeneity" and "neutrophil plasticity" have started to emerge, implying that, under pathological conditions, neutrophils may differentiate into discrete subsets defined by distinct phenotypic and functional profiles. A number of studies have shown that neutrophils act as effectors in both innate and adaptive immunoregulatory networks. In fact, once recruited into inflamed tissues, neutrophils engage into complex bidirectional interactions with macrophages, natural killer, dendritic and mesenchymal stem cells, B and T lymphocytes or platelets. As a result of this crosstalk, mediated either by contact-dependent mechanisms or cell-derived soluble factors, neutrophils and target cells reciprocally modulate their survival and activation status. Altogether, these novel aspects of neutrophil biology have shed a new light not only on the potential complex roles that neutrophils play during inflammation and immune responses, but also in the pathogenesis of several inflammatory disorders including infection, autoimmunity and cancer.

Note:

pii: blood-2014-03-453217

Product ID:

82143

Handle IRIS:

11562/750165

Deposited On:

August 29, 2014

Last Modified:

November 15, 2022

Bibliographic citation:

Scapini, Patrizia; Cassatella, Marco Antonio, Social networking of human neutrophils within the immune system «Blood» , vol. 124 , n. 5 , 2014 , pp. 710-719

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