Pubblicazioni

Autori:

Scapini, Patrizia; Cassatella, Marco Antonio

Titolo:

Social networking of human neutrophils within the immune system

Anno:

2014

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

Sì

Nome rivista:

Blood

ISSN Rivista:

0006-4971

N° Volume:

124

Numero o Fascicolo:

5

Editore:

American Society of Hematology

Intervallo pagine:

710-719

Parole chiave:

neutrophils; neutrophil biology; neutrophil heterogeneity; neutrophil plasticity

Breve descrizione dei contenuti:

It is now widely recognized that neutrophils are highly versatile and sophisticated cells that display de novo synthetic capacity and may greatly extend their lifespan. In addition, concepts such as "neutrophil heterogeneity" and "neutrophil plasticity" have started to emerge, implying that, under pathological conditions, neutrophils may differentiate into discrete subsets defined by distinct phenotypic and functional profiles. A number of studies have shown that neutrophils act as effectors in both innate and adaptive immunoregulatory networks. In fact, once recruited into inflamed tissues, neutrophils engage into complex bidirectional interactions with macrophages, natural killer, dendritic and mesenchymal stem cells, B and T lymphocytes or platelets. As a result of this crosstalk, mediated either by contact-dependent mechanisms or cell-derived soluble factors, neutrophils and target cells reciprocally modulate their survival and activation status. Altogether, these novel aspects of neutrophil biology have shed a new light not only on the potential complex roles that neutrophils play during inflammation and immune responses, but also in the pathogenesis of several inflammatory disorders including infection, autoimmunity and cancer.

Note:

pii: blood-2014-03-453217

Id prodotto:

82143

Handle IRIS:

11562/750165

depositato il:

29 agosto 2014

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Scapini, Patrizia; Cassatella, Marco Antonio, Social networking of human neutrophils within the immune system «Blood» , vol. 124 , n. 5 , 2014 , pp. 710-719

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