Bone involvement and osteoporosis in mastocytosis.
Anno:
2014
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
A Stampa
Referee:
Sì
Nome rivista:
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
ISSN Rivista:
0889-8561
N° Volume:
34
Numero o Fascicolo:
2
Intervallo pagine:
383-396
Parole chiave:
mastocytosis; osteoporosis; bisphosphonate
Breve descrizione dei contenuti:
Bone involvement is frequent in patients with systemic mastocytosis. Osteoporosis is the most prevalent bone manifestation, but diffuse osteosclerosis or focal osteolytic or osteosclerotic lesions are not infrequent. The risk of osteoporotic fractures is high, especially at the spine and in men. Routine measurements of bone mineral density and vertebral morphometry are warranted. The bone turnover markers indicate the involvement of complex bone metabolism in mastocytosis-related manifestations. Bisphosphonates represent the first-line treatment for osteoporosis-related mastocytosis.