Pubblicazioni

Autori:

Artuso, A; Caimmi, Cristian; Tripi, Gaia; Viapiana, Ombretta; Bonifacio, Massimiliano; Idolazzi, Luca; Gavioli, I; Gatti, Davide; Zanotti, Roberta; Rossini, Maurizio

Titolo:

Longitudinal Evaluation of Bone Mineral Density and Bone Metabolism Markers in Patients with Indolent Systemic Mastocytosis Without Osteoporosis

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Calcified Tissue International

ISSN Rivista:

0171-967X

N° Volume:

100

Numero o Fascicolo:

1

Intervallo pagine:

40-46

Parole chiave:

Bone; Indolent systemic mastocytosis; Vitamin D

Breve descrizione dei contenuti:

Systemic Mastocytosis has been long identified as a potential cause of osteoporosis; nevertheless, data regarding longitudinal variation of bone mineral density (BMD) in patients with indolent systemic mastocytosis (ISM) are missing . We studied BMD variation at lumbar spine and proximal hip after 30-month (±6 months) follow-up in a large cohort of patients (83) with ISM without osteoporosis, supplementated with vitamin D and/or calcium when needed. We also analyzed the correlation between variation of BMD, basal serum tryptase levels and bone turnover markers (BTM). Sixty-four percent of our population was male; mean age was 52.1 (±11.5) years. Vitamin D insufficiency (serum levels of 25-OH-vitamin D, 25OHD, lower than 75 nmol/L) was found in more than 70 % of patients. After a follow-up of 30 ± 6 months with only vitamin D (5000-7500 IU weekly of oral cholecalciferol) or calcium (500 mg/die) supplementation when needed, we observed 2.1 % increase in BMD at lumbar spine, with no significant changes at hip. At the end of follow-up, almost 60 % of patients showed 25OHD serum levels still lower than recommended, despite vitamin D supplementation. Reduction in BMD after follow-up significantly correlated with high C-telopeptide of type I collagen serum levels at the time of diagnosis. In patients with ISM without osteoporosis, a routinary BMD evaluation within a time <2 years is not justified, except in the presence of elevated BTM. In these patients, vitamin D supplementation is frequently needed.

Id prodotto:

98025

Handle IRIS:

11562/963978

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Artuso, A; Caimmi, Cristian; Tripi, Gaia; Viapiana, Ombretta; Bonifacio, Massimiliano; Idolazzi, Luca; Gavioli, I; Gatti, Davide; Zanotti, Roberta; Rossini, Maurizio, Longitudinal Evaluation of Bone Mineral Density and Bone Metabolism Markers in Patients with Indolent Systemic Mastocytosis Without Osteoporosis «Calcified Tissue International» , vol. 100 , n. 1 , 2017 , pp. 40-46

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