Publications

Authors:

Angiari, Stefano; Donnarumma, T; Rossi, Barbara; Dusi, Silvia; Pietronigro, Enrica Caterina; Zenaro, Elena; DELLA BIANCA, Vittorina; Toffali, Lara; Piacentino, G; Budui, Simona Luciana; Rennert, P; Xiao, S; Laudanna, Carlo; Casasnovas, Jm; Kuchroo, Vk; Constantin, Gabriela

Title:

TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity

Year:

2014

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

Immunity

ISSN of journal:

1074-7613

N° Volume:

40

Number or Folder:

4

Page numbers:

542-553

Keyword:

autoimmune disease; leukocyte trafficking; Selectins; T cell immunoglobulin; mucin domain 1 (TIM-1)

Short description of contents:

Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rolling of T helper 1 (Th1) and Th17, but not Th2 and regulatory T cells on P-selectin. Th1 and Th17 cells lacking the TIM-1 mucin domain showed reduced rolling in thrombin-activated mesenteric venules and inflamed brain microcirculation. Inhibition of TIM-1 had no effect on naive T cell homing, but it reduced T cell recruitment in a skin hypersensitivity model and blocked experimental autoimmune encephalomyelitis. Uniquely, the TIM-1 immunoglobulin variable domain was also required for P-selectin binding. Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell trafficking during inflammatory responses and the induction of autoimmune disease.

Note:

pii: S1074-7613(14)00084-3

Product ID:

80461

Handle IRIS:

11562/703361

Deposited On:

July 17, 2014

Last Modified:

June 2, 2023

Bibliographic citation:

Angiari, Stefano; Donnarumma, T; Rossi, Barbara; Dusi, Silvia; Pietronigro, Enrica Caterina; Zenaro, Elena; DELLA BIANCA, Vittorina; Toffali, Lara; Piacentino, G; Budui, Simona Luciana; Rennert, P; Xiao, S; Laudanna, Carlo; Casasnovas, Jm; Kuchroo, Vk; Constantin, Gabriela, TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity «Immunity» , vol. 40 , n. 4 , 2014 , pp. 542-553

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