Publications

Authors:

Taraborelli, M.; Ramoni, V.; Brucato, A.; Airò, P.; Bajocchi, G.; Bellisai, F.; Biasi, Domenico; Blagojevic, J.; Canti, V.; Caporali, R.; Caramaschi, Paola; Chiarolanza, I.; Codullo, V.; Cozzi, F.; Cuomo, G.; Cutolo, M.; De Santis, M.; De Vita, Salvatore; Di Poi, E.; Doria, Andrea; Faggioli, P.; Favaro, M.; Ferraccioli, Gianfranco; Ferri, Clodoveo; Foti, R.; Gerosa, A.; Gerosa, M.; Giacuzzo, S.; Giani, L.; Giuggioli, D.; Imazio, M.; Iudici, M.; Iuliano, A.; Leonardi, R.; Limonta, M.; Lojacono, A.; Lubatti, C.; Matucci Cerinic, M.; Mazzone, A.; Meroni, M.; Meroni, P. L.; Mosca, M.; Motta, M.; Muscarà, M.; Nava, S.; Padovan, M.; Pagani, G.; Paolazzi, Giuseppe; Peccatori, S.; Ravagnani, Viviana; Riccieri, V.; Rosato, E.; Rovere Querini, P.; Salsano, F.; Santaniello, A.; Scorza, R.; Tani, C.; Valentini, G.; Valesini, G.; Vanoli, M.; Vigone, B.; Zeni, Silvana; Tincani, Angela

Title:

Brief report: successful pregnancies but a higher risk of preterm births in patients with systemic sclerosis: an Italian multicenter study.

Year:

2012

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Arthritis and Rheumatism

ISSN of journal:

0004-3591

N° Volume:

64

Number or Folder:

6

Page numbers:

1970-1977

Keyword:

pregnancy; systemic sclerosis

Short description of contents:

OBJECTIVE:To assess fetal and maternal outcomes in women with systemic sclerosis (SSc).METHODS:Prospectively collected data on 99 women with SSc from 25 Italian centers were analyzed retrospectively. Women with SSc were observed during 109 pregnancies (from 2000 to 2011), and outcomes were compared to those in the general obstetric population (total of 3,939 deliveries). The maternal age at conception was a mean ± SD 31.8 ± 5.3 years, and the median disease duration at conception was 60 months (range 2-193 months).RESULTS:SSc patients, compared to the general obstetric population, had a significantly increased frequency of preterm deliveries (25% versus 12%) and severe preterm deliveries (<34 weeks of gestation) (10% versus 5%), intrauterine growth restriction (6% versus 1%), and babies with very-low birth weight (5% versus 1%). Results of multivariable analysis showed that corticosteroid use was associated with preterm deliveries (odds ratio [OR] 3.63, 95% confidence interval [95% CI] 1.12-11.78), whereas the use of folic acid (OR 0.30, 95% CI 0.10-0.91) and presence of anti-Scl-70 antibodies (OR 0.26, 95% CI 0.08-0.85) were protective. The disease remained stable in most SSc patients, but there were 4 cases of progression of disease within 1 year from delivery, all in anti-Scl-70 antibody-positive women, 3 of whom had a disease duration of <3 years.CONCLUSION:Women with SSc can have successful pregnancies, but they have a higher-than-normal risk of preterm delivery, intrauterine growth restriction, and babies with very-low birth weight. Progression of the disease during or after pregnancy is rare, but possible. High-risk multidisciplinary management should be standard for these patients, and pregnancy should be avoided in women with severe organ damage and postponed in women with SSc of recent onset, particularly if the patient is positive for anti-Scl-70 antibodies.

Product ID:

75810

Handle IRIS:

11562/501554

Deposited On:

January 21, 2013

Last Modified:

November 27, 2024

Bibliographic citation:

Taraborelli, M.; Ramoni, V.; Brucato, A.; Airò, P.; Bajocchi, G.; Bellisai, F.; Biasi, Domenico; Blagojevic, J.; Canti, V.; Caporali, R.; Caramaschi, Paola; Chiarolanza, I.; Codullo, V.; Cozzi, F.; Cuomo, G.; Cutolo, M.; De Santis, M.; De Vita, Salvatore; Di Poi, E.; Doria, Andrea; Faggioli, P.; Favaro, M.; Ferraccioli, Gianfranco; Ferri, Clodoveo; Foti, R.; Gerosa, A.; Gerosa, M.; Giacuzzo, S.; Giani, L.; Giuggioli, D.; Imazio, M.; Iudici, M.; Iuliano, A.; Leonardi, R.; Limonta, M.; Lojacono, A.; Lubatti, C.; Matucci Cerinic, M.; Mazzone, A.; Meroni, M.; Meroni, P. L.; Mosca, M.; Motta, M.; Muscarà, M.; Nava, S.; Padovan, M.; Pagani, G.; Paolazzi, Giuseppe; Peccatori, S.; Ravagnani, Viviana; Riccieri, V.; Rosato, E.; Rovere Querini, P.; Salsano, F.; Santaniello, A.; Scorza, R.; Tani, C.; Valentini, G.; Valesini, G.; Vanoli, M.; Vigone, B.; Zeni, Silvana; Tincani, Angela, Brief report: successful pregnancies but a higher risk of preterm births in patients with systemic sclerosis: an Italian multicenter study. «Arthritis and Rheumatism» , vol. 64 , n. 6 , 2012 , pp. 1970-1977

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