Publications

Authors:

Moreno, Meneghetti; Gabriele, Marcolongo; Vincenzo, Amendola; Marina, Gobbo; Boscaini, Anita; Fracasso, Giulio; Colombatti, Marco

Title:

SERS IMAGING OF CANCER CELLS WITH ANTIBODY FUNCTIONALIZED GOLD NANOPARTICLES

Year:

2010

Type of item:

Abstract in Atti di convegno

Tipologia ANVUR:

Abstract in Atti di convegno

Language:

Inglese

Format:

A Stampa

Congresso:

Transalpnano 2010

Place:

Como

Period:

GIUGNO 2010

Page numbers:

22-22

Keyword:

SERS; gold nanoparticles; antibody; cell staining

Short description of contents:

Targeting cancer cells with antibodies is a powerful methodology for both tumor imaging and drug delivery. We show how surface enhanced resonance Raman scattering (SERRS) signals of single cells can be obtained engineering gold nanoparticles synthesized by laser ablation. In particular we will use an antibody (D2/B) recognizing the prostate specific membrane antigen (PSMA), overexpressed both in prostate tumors in patients and on LNCaP prostate cancer cells (our “in vitro” tumor model), and Texas Red as SERRS reporter. High intensity signals are observed for LNCaP cells incubated with the targeted nanoparticles and comparison with DU145 cells, which lack PSMA, shows the high targeting specificity of the prepared nanoparticles.

Product ID:

82365

Handle IRIS:

11562/346573

Last Modified:

November 24, 2022

Bibliographic citation:

Moreno, Meneghetti; Gabriele, Marcolongo; Vincenzo, Amendola; Marina, Gobbo; Boscaini, Anita; Fracasso, Giulio; Colombatti, Marco, SERS IMAGING OF CANCER CELLS WITH ANTIBODY FUNCTIONALIZED GOLD NANOPARTICLES  in Book of Abstract , Proceedings of "Transalpnano 2010" , Como , GIUGNO 2010 , 2010 , pp. 22-22

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo