- Authors:
-
Carbone, C.; Melisi, Davide
- Title:
-
NF-κB as a target for pancreatic cancer therapy.
- Year:
-
2012
- Type of item:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Language:
-
Inglese
- Referee:
-
No
- Name of journal:
- EXPERT OPINION ON THERAPEUTIC TARGETS
- ISSN of journal:
- 1472-8222
- Page numbers:
-
1-10
- Keyword:
-
NFkB; TAK1
- Short description of contents:
- Introduction: Pancreatic cancer is the fourth leading cause of adult cancer mortality in the USA. It represents one of the greatest challenges in cancer treatment. The NF-κB transcriptional factors are constitutively activated in the majority of pancreatic cancers and are involved in the regulation of numerous aspects of tumor development and progression. NF-κB and the signaling cascades that regulate its activity have thus become attractive targets for novel therapeutic approaches for pancreatic cancer. Areas covered: This review describes and discusses the most important advances in the comprehension of the complex molecular biology of NF-κB, as well as the development of novel NF-κB-targeting strategies for the treatment of pancreatic cancer. Expert opinion: Although the inhibition of NF-κB, especially when combined with more classic chemotherapeutic drugs, could be a promising therapeutic strategy, direct targeting NF-κB still faces important challenges. In the future, targeting nonredundant cytosolic mediators of the activation of NF-κB - such as TNF receptor associated factor family member-associated NF-κB activator -binding kinase 1 (TBK1) and TGF-beta activated kinase 1 (TAK1) - could represent a better approach to inhibit key processes in pancreatic tumor cells and make a difference for this devastating disease.
- Web page:
-
http://dx.doi.org/10.1517/14728222.2011.645806
- Product ID:
-
66728
- Handle IRIS:
-
11562/393944
- Deposited On:
-
March 27, 2012
- Last Modified:
-
November 15, 2022
- Bibliographic citation:
-
Carbone, C.; Melisi, Davide,
NF-κB as a target for pancreatic cancer therapy.
«EXPERT OPINION ON THERAPEUTIC TARGETS»
,
2012
,
pp. 1-10
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