In this lesson we will describe the “Neutrophil Extracellular Traps (or NETs), filaments of nuclear material released by neutrophil granulocytes into the extracellular environment in response to appropriate inflammatory stimuli. In particular, the physiological role of NETs will be described, i.e. their function of enhancing the immune response against pathogens by increasing their recognition, limiting their spread and promoting their elimination. Furthermore, it will be illustrated how an altered and excessive production of NETs can instead become a pathogenetic mechanism underlying the development of numerous inflammatory and immune pathologies, such as autoimmune diseases and tumors.
In this lesson we will describe the “Neutrophil Extracellular Traps (or NETs), filaments of nuclear material released by neutrophil granulocytes into the extracellular environment in response to appropriate inflammatory stimuli. In particular, the physiological role of NETs will be described, i.e. their function of enhancing the immune response against pathogens by increasing their recognition, limiting their spread and promoting their elimination. Furthermore, it will be illustrated how an altered and excessive production of NETs can instead become a pathogenetic mechanism underlying the development of numerous inflammatory and immune pathologies, such as autoimmune diseases and tumors.
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