Formazione e ricerca

Crediti

0,5

Lingua di erogazione

Italiano e/o Inglese

Frequenza alle lezioni

Scelta Libera

Sede

VERONA

Obiettivi di apprendimento

L'obbiettivo del corso è discutere i meccanismi neuro-fisiologici del prurito,
i principali mediatori chimici coinvolti, la rilevanza clinica del sintomo,
le principali malattie nelle quali il sintomo è dominante e gli aspetti terapeutici del prurito nelle principali patologie.

Prerequisiti e nozioni di base

Il dottorando dovrà dimostrare di sapersi destreggiare nel contesto delle varie metodologie del metodo scientifico

Programma

Pruritus is defined as an unpleasant sensation that provokes the desire to scratch. Pruritus is a common
symptom of numerous inflammatory skin diseases, and it can be severe enough to interfere with sleeping
and daily activities, and impact markedly on patients’ quality of life. Chronic pruritus (CP) is defined
clinically by its persistence for more than 6 weeks and it is a frequent complaint in the general population,
with a 13.5-16.8% point prevalence. CP can be classified on the basis of its underlying aetiology as
dermatological, systemic, neurological, somatoform or multifactorial [3] . The neurophysiology and basic
mechanisms underlying CP have been recently elucidated using animal models and with clinical studies,
contributing to new pathophysiological and therapeutic concepts. CP is a common symptom of a
heterogeneous spectrum of cutaneous inflammatory skin diseases, which have been recently re-classified
according to their immune response pattern, based on specific cellular and cytokine signatures.
The itch sensation usually originates around the dermo-epidermal junction by the activation of selective or
specific nerve endings called pruriceptors. Then, itch is processed and transmitted by specific pathways
through nerves and the spinal cord to the brain. At least two classes of primary afferent C fibers transmit
itch, mechano-insensitive C fibers and mechano-responsive polymodal C-nociceptor units, as well as thinly
myelinated Aδ fibers afferents. Specific receptors located on these fibers can be activated by a large
number of endogenous itch-inducing agents released by keratinocytes, immune cells or neighbouring
neuronal afferent and exogenous agents, such as proteases released by Staphylococcus aureus. These
sensory neurons have cell bodies in the dorsal root ganglion (DRG) and project primary afferents to the
skin, and they send projections to the dorsal horn of the spinal cord, where they synapse with second- or
third-order neurons, that come together to form part of the spinothalamic tract, which then ascends up to
the thalamus and proceed to the somatosensory and the anterior cingulate cortex. Second- and third-order
neurons in the spinal cord may have either excitatory or inhibitory functions. Pathways of itch are complex
and not fully established. Moreover, pruritus and pain pathways are largely overlapped and interrelated,
though the exact relationships are still a matter of debate. Several chemical pruritogens and some physical
stimuli have been experimentally used to elicit itch to investigate pruritus pathways and test potential anti-
pruritic drugs. However, no objective methods to elicit and to evaluate itch have been standardized.
Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus may
have a tremendous impact on the patients’ quality of life and strongly interfere with sleep, social and work
activities. We review the role of type-2 inflammation and immunity in the pathogenesis of chronic pruritic
conditions of the skin. Type 2 cytokines, including IL-4, IL-13, thymic stromal lymphopoietin, periostin, IL-
31, IL-25 and IL-33 are released by mast cells, innate lymphoid cells 2, keratinocytes and type 2 T
lymphocytes and are master regulators of chronic itch. These cytokines may act as direct pruritogen on
primary sensory neurons (pruriceptors) or alter the sensitivity to other itch mediators Type 2 inflammation-
and immunity-dominated skin diseases, including atopic dermatitis, prurigo nodularis, bullous pemphigoid,
scabies, parasitic diseases, urticaria, and Sézary syndrome are indeed conditions associated with most
severe pruritus. In contrast, in other skin diseases, such as scleroderma, lupus erythematosus, hidradenitis
suppurativa, and acne, type 2 inflammation is less represented, and pruritus is milder or variable. Th2
inflammation and immunity have evolved to protect against parasites, and thus, the scratching response
evoked by pruritus may have developed to alert about the presence and to remove parasites from the skin
surface.

Quando e Dove

Lezioni frontali
Incontri individuali

Modalità di verifica dell'apprendimento

Colloquio orale

Le/gli studentesse/studenti con disabilità o disturbi specifici di apprendimento (DSA), che intendano richiedere l'adattamento della prova d'esame, devono seguire le indicazioni riportate QUI

Valutazione

Valutazione delle abilità nel progettare attività di ricerca del dottorando

Criteri di composizione del voto finale

Idoneità

Attività Formative della Scuola di Dottorato - 2023/2024

Please note: Additional information will be added during the year. Currently missing information is labelled as “TBD” (i.e. To Be Determined).

PhD students must obtain a specified number of CFUs each year by attending teaching activities offered by the PhD School.
First and second year students must obtain 8 CFUs. Teaching activities ex DM 226/2021 provide 5 CFUs; free choice activities provide 3 CFUs.
Third year students must obtain 4 CFUs. Teaching activities ex DM 226/2021 provide 2 CFUs; free choice activities provide 2 CFUs.

Registering for the courses is not required unless explicitly indicated; please consult the course information to verify whether registration is required or not. When registration is actually required, no confirmation e-mail will be sent after signing up.

Activities are also listed in the online calendar.

Teaching Activities ex DM 226/2021: Linguistic Activities

Teaching Activities ex DM 226/2021: Research management and Enhancement

Teaching Activities ex DM 226/2021: Statistics and Computer Sciences

Generalized linear models: logistic regression, loglinear model, Poisson model

Crediti: 2

Lingua di erogazione: English

Docente:  Lucia Cazzoletti

STUDY DESIGN IN OBSERVATIONAL AND EXPERIMENTAL RESEARCH

Crediti: 1,5

Lingua di erogazione: English

Docente:  Alessandro Marcon

DETERMINATION OF SAMPLE SIZE TO ACHIEVE A PREDEFINED PRECISION OR POWER

Crediti: 1

Lingua di erogazione: Inglese

Docente:  Giuseppe Verlato

INTRODUCTION TO META-ANALYSIS, FOCUSED ON MEDICAL RESEARCH (LITERATURE REVIEW, DATA COLLECTION, DATABASE CONSTRUCTION)

Crediti: 1

Lingua di erogazione: English

Docente:  Giuseppe Verlato

APPLICATION OF META-ANALYSIS TO THE EPIDEMIOLOGICAL OR MEDICAL FIELD

Crediti: 1

Lingua di erogazione: Inglese

Docente:  Giuseppe Verlato

Survival analysis: log-rank test, Kaplan-Meier survival curves, Cox regression model

Crediti: 1,5

Lingua di erogazione: Inglese

Docente:  Simone Accordini

Application of meta-analysis to the epidemiological or medical field

Crediti: 1

Lingua di erogazione: English

Docente:  Giuseppe Verlato

INTERMEDIATE STATISTICS [Recommended for Human Sciences]

Crediti: 2,5

Lingua di erogazione: Inglese

INTERMEDIATE STATISTICS [Tutti i corsi di studio]

Crediti: 2,5

Lingua di erogazione: Inglese

Introduction to meta-analysis, focused on medical research (literature review, data collection, database construction)

Crediti: 1

Lingua di erogazione: English

Statistical analysis with R - module II

Crediti: 2

Lingua di erogazione: Italiano

Docente:  Erica Secchettin

Teaching Activities: Free choice

Docenti

B C D F G K L M R S T V Z

Battaglia Yuri

symbol email yuri.battaglia@univr.it

Bertoldo Francesco

symbol email francesco.bertoldo@univr.it symbol phone-number +39 045 812 6485

Carrara Elena

symbol email elena.carrara@univr.it

Chiarini Anna Maria

symbol email anna.chiarini@univr.it symbol phone-number +39 045 802 7646

Ciccocioppo Rachele

symbol email rachele.ciccocioppo@univr.it symbol phone-number 045 8124466

Crisafulli Ernesto

symbol email ernesto.crisafulli@univr.it symbol phone-number +39 045 812 8146

Dal Prà Ilaria Pierpaola

symbol email ilaria.dalpra@univr.it symbol phone-number +39 045 802 7161

Fantin Francesco

symbol email francesco.fantin@univr.it symbol phone-number +39 045 812 3577

Fava Cristiano

symbol email cristiano.fava@univr.it symbol phone-number +39 045 8124732

Fratta Pasini Anna Maria

symbol email annamaria.frattapasini@univr.it symbol phone-number +39 045 8124749

Frulloni Luca

symbol email luca.frulloni@univr.it symbol phone-number 045 8124466

Gatti Davide

symbol email davide.gatti@univr.it

Girolomoni Giampiero

symbol email giampiero.girolomoni@univr.it symbol phone-number +39 045 812 2547

Gisondi Paolo

symbol email paolo.gisondi@univr.it symbol phone-number +39 045 812 2547

Krampera Mauro

symbol email mauro.krampera@univr.it symbol phone-number 0458124034

Lanza Massimo

symbol email massimo.lanza@univr.it symbol phone-number +39 0458425118

Mantovani Alessandro

symbol email alessandro.mantovani@univr.it symbol phone-number 0458127672

Mazzali Gloria

symbol email gloria.mazzali@aovr.veneto.it symbol phone-number +39 045 807 3577

Minuz Pietro

symbol email pietro.minuz@univr.it symbol phone-number +39 045 812 4414

Romano Simone

symbol email simone.romano@univr.it symbol phone-number 0458124414

Rossini Maurizio

symbol email maurizio.rossini@libero.it symbol phone-number +39 045 8126338

Sacerdoti David

symbol email DAVID.SACERDOTI@UNIVR.IT symbol phone-number 0458128159

Targher Giovanni

symbol email giovanni.targher@univr.it symbol phone-number +39 045 8123748

Trifirò Gianluca

symbol email gianluca.trifiro@univr.it symbol phone-number 0458027612

Viapiana Ombretta

symbol email ombretta.viapiana@univr.it symbol phone-number +39 045 812 4049

Zamboni Mauro

symbol email mauro.zamboni@univr.it symbol phone-number +39 045 812 2537

Zoico Elena

symbol email elena.zoico@univr.it symbol phone-number +39 045 812-2537

Zoppini Giacomo

symbol email giacomo.zoppini@univr.it symbol phone-number +39 045 8123115

Dottorandi

Dottorandi presenti nel:

Non è presente alcuna persona. 40° Ciclo non iniziato.

Lezioni del Corso
Lezioni della Scuola di Dottorato

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Linee guida percorso formativo

Di seguito i file che contengono le Linee guida per il percorso formativo e il regolamento per l'acquisizione dei crediti formativi (CFU) per l'Anno Accademico 2023/2024.