Development of a new anti-inflammatory pharmacological approach for the treatment of septic shock

Data inizio: 1 settembre 2006
Durata (mesi): 12
Responsabili (o referenti locali): Laudanna Carlo
Parole chiave: Septic shock, Leukocyte recruitment, Cytokine, Oxidative stress, Signal transduction

Identification and characterization of novel V-ATPases inhibitors able to interfere adhesive and pro-inflammatory activities of leukocytes in in vitro assays.
1. Effect of V-ATPase inhibitors on rapid integrin activation and dependent adhesion
2. Effect of V-APTase inhibitors on chemotaxis
3. Effect of V-APTase inhibitors on generation of oxygen free-radicals (oxidative stress)
4. Effect of V-ATPase inhibitors on pro-inflammatory cytokine production
Pharmacological characterization of the capability of V-ATPases inhibitors onset and/or to reduce the severity of septic shock in animal models.
1. Effect of V-ATP-ase inhibitors on onset and progression of septic shock
2. Identification of compound-related activity, best dosage and toxic effect

Enti finanziatori:

: Finanziamento: assegnato e gestito dal Dipartimento

Partecipanti al progetto

Simone Dorothea Bach
Matteo Bolomini Vittori
Gabriela Constantin: Professore ordinario
Cinzia Giagulli

Carlo Laudanna: Professore ordinario
Marianna Martinello
Barbara Rossi