Development of a new anti-inflammatory pharmacological approach for the treatment of septic shock

Starting date: September 1, 2006
Duration (months): 12
Managers or local contacts: Laudanna Carlo
Keyword: Septic shock, Leukocyte recruitment, Cytokine, Oxidative stress, Signal transduction

Identification and characterization of novel V-ATPases inhibitors able to interfere adhesive and pro-inflammatory activities of leukocytes in in vitro assays.
1. Effect of V-ATPase inhibitors on rapid integrin activation and dependent adhesion
2. Effect of V-APTase inhibitors on chemotaxis
3. Effect of V-APTase inhibitors on generation of oxygen free-radicals (oxidative stress)
4. Effect of V-ATPase inhibitors on pro-inflammatory cytokine production
Pharmacological characterization of the capability of V-ATPases inhibitors onset and/or to reduce the severity of septic shock in animal models.
1. Effect of V-ATP-ase inhibitors on onset and progression of septic shock
2. Identification of compound-related activity, best dosage and toxic effect

Sponsors:

: Funds: assigned and managed by the department

Project participants

Simone Dorothea Bach
Matteo Bolomini Vittori
Gabriela Constantin: Full Professor
Cinzia Giagulli

Carlo Laudanna: Full Professor
Marianna Martinello
Barbara Rossi