This project is finalized to the constitution of a network of laboratories interested to characterize the mechanisms that regulate cell adhesion and its role in the control of cell movement, proliferation and survival.
The aims of the proposed network of laboratories can be briefly indicated as the follows:
- identification of the mechanisms regulating leukocyte/endothelium adhesion and determining the recruitment of inflammatory and immune cells in the tissues;
- identification of the integrin-dependent signal transduction mechanisms involved in the control of cell movement, proliferation and survival.
The responsibility of this unit within this research project can be summarized as follows:
- definition of new model of experimental inflammation allowing us to reinforce the demonstratation that Fgr and Hck regulate recruitment of granulocytes in sites of inflammation;
- characterization of the signal transduction pathway implicated in regulation of cell movement by Fgr.