Publications

Authors:

Cavaliere, Alessandro; Merz, Valeria; Casalino, Simona; Zecchetto, Camilla; Simionato, Francesca; Salt, Hayley Louise; Contarelli, Serena; Santoro, Raffaela; Melisi, Davide

Title:

Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer

Year:

2019

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF GASTRIC CANCER

ISSN of journal:

2093-582X

N° Volume:

19

Number or Folder:

4

Page numbers:

375-392

Keyword:

Baculoviral IAP repeat-containing 3 protein; Gastric cancer; HOXB9 protein, human; Microsatellite instability; Receptor, fibroblast growth factor, type 3

Short description of contents:

Preoperative chemo- and radiotherapeutic strategies followed by surgery are currently a standard approach for treating locally advanced gastric and esophagogastric junction cancer in Western countries. However, in a large number of cases, the tumor is extremely resistant to these treatments and the patients are exposed to unnecessary toxicity and delayed surgical therapy. The current clinical trials evaluating the combination of preoperative systemic therapies with modern targeted and immunotherapeutic agents represent a unique opportunity for identifying predictive biomarkers of response to select patients that would benefit the most from these treatments. However, it is of utmost importance that these potential biomarkers are corroborated by extensive preclinical and translational research. The aim of this review article is to present the most promising biomarkers of response to classic chemotherapeutic, anti-HER2, antiangiogenic, and immunotherapeutic agents that can be potentially useful for personalized preoperative systemic therapies in gastric cancer patients.

Product ID:

113550

Handle IRIS:

11562/1014050

Last Modified:

November 15, 2022

Bibliographic citation:

Cavaliere, Alessandro; Merz, Valeria; Casalino, Simona; Zecchetto, Camilla; Simionato, Francesca; Salt, Hayley Louise; Contarelli, Serena; Santoro, Raffaela; Melisi, Davide, Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer «JOURNAL OF GASTRIC CANCER» , vol. 19 , n. 4 , 2019 , pp. 375-392

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