Pubblicazioni

Autori:

Caocci, Giovanni; Mulas, Olga; Annunziata, Mario; Luciano, Luigiana; Abruzzese, Elisabetta; Bonifacio, Massimiliano; Orlandi, Ester Maria; Albano, Francesco; Galimberti, Sara; Iurlo, Alessandra; Pregno, Patrizia; Sgherza, Nicola; Martino, Bruno; Binotto, Gianni; Castagnetti, Fausto; Gozzini, Antonella; Bocchia, Monica; Fozza, Claudio; Stagno, Fabio; Simula, Maria Pina; De Gregorio, Fiorenza; Trawinska, Malgorzata Monika; Scaffidi, Luigi; Elena, Chiara; Attolico, Imma; Baratè, Claudia; Cattaneo, Daniele; Pirillo, Francesca; Gugliotta, Gabriele; Sicuranza, Anna; Molica, Matteo; La Nasa, Giorgio; Foà, Robin; Breccia, Massimo

Titolo:

Long-term mortality rate for cardiovascular disease in 656 chronic myeloid leukaemia patients treated with second- and third-generation tyrosine kinase inhibitors

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

International Journal of Cardiology

ISSN Rivista:

0167-5273

N° Volume:

301

Intervallo pagine:

163-166

Parole chiave:

Cardiovascular toxicity; Chronic myeloid leuk; Ischemic heart disease; TKI; a; emia

Breve descrizione dei contenuti:

Background: Limited information is available regarding the rate of long-term cardiovascular (CV) mortality in chronic myeloid leukaemia (CML) patients treated with second- and third-generation tyrosine kinase inhibitors (2nd(G)/3rd(G) TKIs) in the real-life practice.Methods: We identified 656 consecutive CML patients treated with nilotinib, dasatinib, bosutinib and ponatinib.Results: The 15-year CV-mortality free survival was 93 +/- 2.8%. Age >= 65 years (p = 0.005) and a positive history of CV disease (p = 0.04) were significantly associated with a lower CV-mortality free survival. CV disease accounted for 16.5% and 5% of potential years of life lost (PYLL) in male and female patients, respectively. The standard mortality ratio (SMR) following ischemic heart disease (IHD) was 3.9 in males and 3.8 in female patients, meaning an excess of IHD deaths observed, in comparison with the population of control. Conclusion. Prevention strategies based on CV risk factors, in particular in those patients with a previous history of CV disease, should be considered. (C) 2019 Elsevier B.V. All rights reserved.

Id prodotto:

113951

Handle IRIS:

11562/1015869

ultima modifica:

28 novembre 2022

Citazione bibliografica:

Caocci, Giovanni; Mulas, Olga; Annunziata, Mario; Luciano, Luigiana; Abruzzese, Elisabetta; Bonifacio, Massimiliano; Orlandi, Ester Maria; Albano, Francesco; Galimberti, Sara; Iurlo, Alessandra; Pregno, Patrizia; Sgherza, Nicola; Martino, Bruno; Binotto, Gianni; Castagnetti, Fausto; Gozzini, Antonella; Bocchia, Monica; Fozza, Claudio; Stagno, Fabio; Simula, Maria Pina; De Gregorio, Fiorenza; Trawinska, Malgorzata Monika; Scaffidi, Luigi; Elena, Chiara; Attolico, Imma; Baratè, Claudia; Cattaneo, Daniele; Pirillo, Francesca; Gugliotta, Gabriele; Sicuranza, Anna; Molica, Matteo; La Nasa, Giorgio; Foà, Robin; Breccia, Massimo, Long-term mortality rate for cardiovascular disease in 656 chronic myeloid leukaemia patients treated with second- and third-generation tyrosine kinase inhibitors «International Journal of Cardiology» , vol. 301 , 2020 , pp. 163-166

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