Publications

Authors:

Baccarani, Michele; Abruzzese, Elisabetta; Accurso, Vincenzo; Albano, Francesco; Annunziata, Mario; Barulli, Sara; Beltrami, Germana; Bergamaschi, Micaela; Binotto, Gianni; Bocchia, Monica; Caocci, Giovanni; Capodanno, Isabella; Cavazzini, Francesco; Cedrone, Michele; Cerrano, Marco; Crugnola, Monica; D'Adda, Mariella; Elena, Chiara; Fava, Carmen; Fazi, Paola; Fozza, Claudio; Galimberti, Sara; Giai, Valentina; Gozzini, Antonella; Gugliotta, Gabriele; Iurlo, Alessandra; La Barba, Gaetano; Levato, Luciano; Lucchesi, Alessandro; Luciano, Luigia; Lunghi, Francesca; Lunghi, Monia; Malagola, Michele; Marasca, Roberto; Martino, Bruno; Melpignano, Angela; Miggiano, Maria Cristina; Montefusco, Enrico; Musolino, Caterina; Palmieri, Fausto; Pregno, Patrizia; Rapezzi, Davide; Rege-Cambrin, Giovanna; Rupoli, Serena; Salvucci, Marzia; Sancetta, Rosaria; Sica, Simona; Spadano, Raffaele; Stagno, Fabio; Tiribelli, Mario; Tomassetti, Simona; Trabacchi, Elena; Bonifacio, Massimiliano; Breccia, Massimo; Castagnetti, Fausto; Pane, Fabrizio; Russo, Domenico; Saglio, Giuseppe; Soverini, Simona; Vigneri, Paolo; Rosti, Gianantonio

Title:

Managing chronic myeloid leukemia for treatment-free remission: a proposal from the GIMEMA CML WP

Year:

2019

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

BLOOD ADVANCES

ISSN of journal:

2473-9529

N° Volume:

3

Number or Folder:

24

Page numbers:

4280-4290

Keyword:

chronic myeloid leukemia,management,recommendations,Gimema,treatment-free remission

Short description of contents:

Several papers authored by international experts have proposed recommendations on the management of BCR-ABL1(+) chronic myeloid leukemia (CML). Following these recommendations, survival of CML patients has become very dose to normal. The next, ambitious, step is to bring as many patients as possible into a condition of treatment-free remission (TFR). The Gruppo Italian Malattie EMatologiche dell'Adulto (GIMEMA; Italian Group for Hematologic Diseases of the Adult) CML Working Party (WP) has developed a project aimed at selecting the treatment policies that may increase the probability of TFR, taking into account 4 variables: the need for TFR, the tyrosine kinase inhibitors (TKIs), the characteristics of leukemia, and the patient. A Delphi-like method was used to reach a consensus among the representatives of SO centers of the CML WP. A consensus was reached on the assessment of disease risk (EUTOS Long Term Survival LELTS) score), on the definition of the most appropriate age boundaries for the choice of first-line treatment, on the choice of the TKI for first-line treatment, and on the definition of the responses that do not require a change of the TKI (BCR-ABL1 <= 1.0% at 3 months, <= 1% at 6 months, <= 0.1% at 12 months, <= 0.01% at 24 months), and of the responses that require a change of the TKI, when the goal is TFR (BCR-ABL1 >10% at 3 and 6 months, >1% at 12 months, and >0.1% at 24 months). These suggestions may help optimize the treatment strategy for TFR.

Product ID:

113946

Handle IRIS:

11562/1015876

Last Modified:

November 15, 2022

Bibliographic citation:

Baccarani, Michele; Abruzzese, Elisabetta; Accurso, Vincenzo; Albano, Francesco; Annunziata, Mario; Barulli, Sara; Beltrami, Germana; Bergamaschi, Micaela; Binotto, Gianni; Bocchia, Monica; Caocci, Giovanni; Capodanno, Isabella; Cavazzini, Francesco; Cedrone, Michele; Cerrano, Marco; Crugnola, Monica; D'Adda, Mariella; Elena, Chiara; Fava, Carmen; Fazi, Paola; Fozza, Claudio; Galimberti, Sara; Giai, Valentina; Gozzini, Antonella; Gugliotta, Gabriele; Iurlo, Alessandra; La Barba, Gaetano; Levato, Luciano; Lucchesi, Alessandro; Luciano, Luigia; Lunghi, Francesca; Lunghi, Monia; Malagola, Michele; Marasca, Roberto; Martino, Bruno; Melpignano, Angela; Miggiano, Maria Cristina; Montefusco, Enrico; Musolino, Caterina; Palmieri, Fausto; Pregno, Patrizia; Rapezzi, Davide; Rege-Cambrin, Giovanna; Rupoli, Serena; Salvucci, Marzia; Sancetta, Rosaria; Sica, Simona; Spadano, Raffaele; Stagno, Fabio; Tiribelli, Mario; Tomassetti, Simona; Trabacchi, Elena; Bonifacio, Massimiliano; Breccia, Massimo; Castagnetti, Fausto; Pane, Fabrizio; Russo, Domenico; Saglio, Giuseppe; Soverini, Simona; Vigneri, Paolo; Rosti, Gianantonio, Managing chronic myeloid leukemia for treatment-free remission: a proposal from the GIMEMA CML WP «BLOOD ADVANCES» , vol. 3 , n. 24 , 2019 , pp. 4280-4290

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo