Publications

Authors:

Merz, Valeria; Zecchetto, Camilla; Santoro, Raffaela; Simionato, Francesca; Sabbadini, Fabio; Mangiameli, Domenico; Piro, Geny; Cavaliere, Alessandro; Deiana, Michaela; Valenti, Maria Teresa; Bazan, Diana; Fedele, Vita; Lonardi, Sara; Melisi, Davide

Title:

Plasma Interleukin-8 is a biomarker for TAK1 activation and predicts resistance to nanoliposomal irinotecan in patients with gemcitabine-refractory pancreatic cancer

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Clinical Cancer Research

ISSN of journal:

1078-0432

N° Volume:

26

Number or Folder:

17

Page numbers:

4661-4669

Keyword:

TAK1

Short description of contents:

Pancreatic cancer is one of the most lethal solid tumors, mainly because of its intrinsic chemoresistance. We identified TAK1 as a central hub sustaining this resistance. Nanoliposomal irinotecan (nal-IRI)is a novel treatment for metastatic gemcitabine-refractory pancreatic cancer. We endeavored to identify circulating markers for TAK1 activation predicting chemoresistance in this setting.

Product ID:

114875

Handle IRIS:

11562/1019359

Last Modified:

January 26, 2025

Bibliographic citation:

Merz, Valeria; Zecchetto, Camilla; Santoro, Raffaela; Simionato, Francesca; Sabbadini, Fabio; Mangiameli, Domenico; Piro, Geny; Cavaliere, Alessandro; Deiana, Michaela; Valenti, Maria Teresa; Bazan, Diana; Fedele, Vita; Lonardi, Sara; Melisi, Davide, Plasma Interleukin-8 is a biomarker for TAK1 activation and predicts resistance to nanoliposomal irinotecan in patients with gemcitabine-refractory pancreatic cancer «Clinical Cancer Research» , vol. 26 , n. 17 , 2020 , pp. 4661-4669

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