Publications

Authors:

Piona, Claudia; Cozzini, Tiziano; Marchini, Giorgio; Merz, Tommaso; Brighenti, Tommaso; Mazzo, Umberto; Marigliano, Marco; Olivieri, Francesca; Pedrotti, Emilio; Maffeis, Claudio

Title:

Reduced minimum rim width of optic nerve head: a potential early marker of retinal neurodegeneration in children and adolescents with type 1 diabetes

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

Diabetes Research and Clinical Practice

ISSN of journal:

0168-8227

N° Volume:

169

Number or Folder:

108420

Page numbers:

1-9

Keyword:

Diabetic retinopathy; Minimal neuroretinal rim width; Retinal neurodegeneration; Spectral domain optical coherence tomography; Type 1 Diabetes

Short description of contents:

Aims: To determine whether early retinal neurodegenerative changes in pediatric patients with type 1 diabetes (T1D) can be detected by spectral domain-optical coherence tomography (SD-OCT) and whether such changes are associated with risk factors for T1D complications. Methods: A total of 147 T1D children/adolescents and 51 healthy controls underwent SD-OCT. Spherical refractive error (SRE), macular total retinal thickness (TRT), ganglion cell layer (GCL), retinal nerve fiber layer (RNFL), minimum rim width (MRW), and Bruch's membrane opening area (BMOA) were measured. Clinical and biochemical parameters were recorded at the time of SD-OCT and starting at T1D onset. Multiple regression models were calculated using SD-OCT parameters as dependent and risk factors as independent variables. Results: MRW was significantly thinner in the T1D patients (global MRW:361.58vs386.33µm;p=0.009), while RNFL and macular parameters were similar for both groups. MRW was inversely correlated with mean HbA1c (r≥-0.180,p<0.05). Multiple regression showed that part of the variability in MRW was explained by HbA1c and BMOA (R2 =0.21;p< 0.001), independent of other cardiometabolic risk factors. Conclusions: MRW reduction could be a potential early marker of retinal neurodegeneration detectable in pediatric patients with T1D. The association between MRW and mean HbA1c suggests that glucometabolic control may affect early retinal neurodegeneration starting in childhood.

Note:

Claudia Piona and Tiziano Cozzini contributed equally to this work. Emilio Pedrotti and Claudio Maffeis contributed equally to this work.

Web page:

https://doi.org/10.1016/j.diabres.2020.108420

Product ID:

115991

Handle IRIS:

11562/1024361

Last Modified:

November 15, 2022

Bibliographic citation:

Piona, Claudia; Cozzini, Tiziano; Marchini, Giorgio; Merz, Tommaso; Brighenti, Tommaso; Mazzo, Umberto; Marigliano, Marco; Olivieri, Francesca; Pedrotti, Emilio; Maffeis, Claudio, Reduced minimum rim width of optic nerve head: a potential early marker of retinal neurodegeneration in children and adolescents with type 1 diabetes «Diabetes Research and Clinical Practice» , vol. 169 , n. 108420 , 2020 , pp. 1-9

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