Publications

Authors:

Fornari, Elena; Morandi, Anita; Piona, Claudia; Tommasi, Mara; Corradi, Massimiliano; Maffeis, Claudio

Title:

Policaptil Gel Retard Intake Reduces Postprandial Triglycerides, Ghrelin and Appetite in Obese Children: A Clinical Trial

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

NUTRIENTS

ISSN of journal:

2072-6643

N° Volume:

12

Number or Folder:

1

Page numbers:

214-222

Keyword:

appetite; children; fibers; ghrelin; obesity; postprandial phase; triglycerides; Appetite; Blood Glucose; Child; Double-Blind Method; Eating; Female; Gels; Ghrelin; Humans; Insulin; Macromolecular Substances; Male; Pediatric Obesity; Polysaccharides; Postprandial Period; Triglycerides

Short description of contents:

The aim of this study is to test the hypothesis that the intake of Policaptil Gel Retard((R)) (PGR) is able to affect appetite, metabolic and hormonal postprandial profile in obese children. 46 obese children were randomly assigned to treatment with PGR or placebo, in a double blind clinical trial. Two PGR tablets or placebo were given in fasting condition, before the ingestion of a mixed meal (15 kcal/kg lean body mass). Blood samples were taken at baseline and for 4 h, for measuring blood lipids, glucose, insulin, ghrelin, and glucagon like peptide-1 (GLP-1). Appetite was quantified using a visual analog scale. Children assuming PGR had a significantly lower increase of postprandial triglycerides (area under the curve (AUC): 3021 (2879) vs. 5038 (3738) mg x 240 min/Dl) and appetite (-234 (274) vs. 36 (329)) than children assuming placebo. The AUC of ghrelin was significantly lower after PGR ingestion, than after placebo (-8179 (8073) vs. -2800 (7579) pg x 240 min/mL). Blood glucose, insulin, non-esterified fatty acids (NEFA) and GLP-1 profiles were not significantly different in the two groups. In conclusion, a single intake of two tablets of PGR was associated with a significant reduction of appetite, ghrelin, and triglycerides in the postprandial period in obese children. Further investigation will assess if a chronic intake of PGR may affect body weight and glucose metabolism.

Product ID:

117616

Handle IRIS:

11562/1029958

Last Modified:

November 12, 2022

Bibliographic citation:

Fornari, Elena; Morandi, Anita; Piona, Claudia; Tommasi, Mara; Corradi, Massimiliano; Maffeis, Claudio, Policaptil Gel Retard Intake Reduces Postprandial Triglycerides, Ghrelin and Appetite in Obese Children: A Clinical Trial «NUTRIENTS» , vol. 12 , n. 1 , 2020 , pp. 214-222

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