Publications

Authors:

Facchinetti, Francesco; Mazzaschi, Giulia; Barbieri, Fausto; Passiglia, Francesco; Mazzoni, Francesca; Berardi, Rossana; Proto, Claudia; Cecere, Fabiana Letizia; Pilotto, Sara; Scotti, Vieri; Rossi, Sabrina; Del Conte, Alessandro; Vita, Emanuele; Bennati, Chiara; Ardizzoni, Andrea; Cerea, Giulio; Migliorino, Maria Rita; Sala, Elisa; Camerini, Andrea; Bearz, Alessandra; De Carlo, Elisa; Zanelli, Francesca; Guaitoli, Giorgia; Garassino, Marina Chiara; Ciccone, Lucia Pia; Sartori, Giulia; Toschi, Luca; Dall'Olio, Filippo Gustavo; Landi, Lorenza; Pizzutilo, Elio Gregory; Bartoli, Gabriele; Baldessari, Cinzia; Novello, Silvia; Bria, Emilio; Cortinovis, Diego Luigi; Rossi, Giulio; Rossi, Antonio; Banna, Giuseppe Luigi; Camisa, Roberta; Di Maio, Massimo; Tiseo, Marcello

Title:

First-line pembrolizumab in advanced non-small cell lung cancer patients with poor performance status

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

European Journal of Cancer

ISSN of journal:

0959-8049

N° Volume:

130

Page numbers:

155-167-167

Keyword:

ECOG PS 2; Immune checkpoint inhibitors; Immunotherapy; NSCLC; PD-1

Short description of contents:

Background: Pembrolizumab is the first-line standard of care for advanced non-small cell lung cancer (NSCLC) with a PD-L1 tumour proportion score (TPS) >= 50%. Eastern Cooperative Oncology Group performance status (PS) 2 patients may receive pembrolizumab, despite the absence of sustaining evidence.Patients and methods: GOIRC-2018-01 is a multicentre, retrospective, observational study. PS 2 NSCLC patients with a PD-L1 TPS >= 50% receiving first-line pembrolizumab from June 2017 to December 2018 at 21 Italian institutions were included. Clinical-pathological characteristics were correlated with disease response and survival outcomes; adverse events were recorded. The primary objective was 6-months progression-free rate (6-months PFR).Results: One hundred fifty-three patients (median age 70 years) were enrolled. At a median follow-up of 18.2 months, median progression-free survival (PFS) and overall survival (OS) were 2.4 (95% confidence interval, 95% CI, 1.6-2.5) and 3.0 months (95% CI 2.4-3.5), respectively. 6-months PFR was 27% (95% CI 21-35%). Patients with a PS 2 determined by comorbidities (n = 41) had significantly better outcomes compared with disease burden-induced PS 2 (n = 112). Indeed, 6-months PFR was 49% versus 19%, median PFS 5.6 versus 1.8 months and OS 11.8 versus 2.8 months, respectively. Additional potential prognostic factors (radiotherapy, antibiotics, steroids received before pembrolizumab) correlated with clinical outcomes. The determinant of PS 2 resulted the only factor independently impacting on both PFS and OS. No toxicity issues emerged.Conclusions: Outcomes of PS 2 NSCLC patients with PD-L1 TPS >= 50% receiving first-line pembrolizumab were globally dismal but strongly dependent on the reason conditioning the poor PS itself. (C) 2020 Elsevier Ltd. All rights reserved.

Product ID:

117647

Handle IRIS:

11562/1030196

Last Modified:

February 1, 2025

Bibliographic citation:

Facchinetti, Francesco; Mazzaschi, Giulia; Barbieri, Fausto; Passiglia, Francesco; Mazzoni, Francesca; Berardi, Rossana; Proto, Claudia; Cecere, Fabiana Letizia; Pilotto, Sara; Scotti, Vieri; Rossi, Sabrina; Del Conte, Alessandro; Vita, Emanuele; Bennati, Chiara; Ardizzoni, Andrea; Cerea, Giulio; Migliorino, Maria Rita; Sala, Elisa; Camerini, Andrea; Bearz, Alessandra; De Carlo, Elisa; Zanelli, Francesca; Guaitoli, Giorgia; Garassino, Marina Chiara; Ciccone, Lucia Pia; Sartori, Giulia; Toschi, Luca; Dall'Olio, Filippo Gustavo; Landi, Lorenza; Pizzutilo, Elio Gregory; Bartoli, Gabriele; Baldessari, Cinzia; Novello, Silvia; Bria, Emilio; Cortinovis, Diego Luigi; Rossi, Giulio; Rossi, Antonio; Banna, Giuseppe Luigi; Camisa, Roberta; Di Maio, Massimo; Tiseo, Marcello, First-line pembrolizumab in advanced non-small cell lung cancer patients with poor performance status «European Journal of Cancer» , vol. 130 , 2020 , pp. 155-167-167

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo