Publications

Authors:

Facchinelli, Davide; Parisi, Alice; Krampera, Mauro; Veneri, Dino

Title:

Is triple-positive serology for Epstein-Barr virus (VCA-IgG, VCA-IgM, EBNA-IgG) a specific feature of angioimmunoblastic T-cell lymphoma?

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Tumori

ISSN of journal:

0300-8916

N° Volume:

106

Number or Folder:

5

Page numbers:

424-426

Keyword:

Angioimmunoblastic T-cell lymphoma; Epstein-Barr virus; serology for acute infection; Adult; Aged; Aged, 80 and over; Antigens, Viral; Capsid Proteins; Epstein-Barr Virus Nuclear Antigens; Female; Humans; Immunoglobulin G; Immunoglobulin M; Lymphoma, T-Cell; Male; Middle Aged; Retrospective Studies; Serology

Short description of contents:

Purpose: We assessed the frequency of triple-positive serology (viral capsid antigen [VCA]-immunoglobulin G [IgG], VCA-immunoglobulin M, Epstein-Barr nuclear antigen-IgG) for Epstein-Barr virus (EBV) in a small number of patients with angioimmunoblastic T-cell lymphoma (AITL) at disease onset. Methods: Nine patients with newly diagnosed AITL were retrospectively enrolled in the present study. For all of them, EBV serology data were available. Results: Of 9 patients, 7 (77.7%) had a triple-positive serology (VCA-IgG, VCA-IgM, EBNA-IgG ) for EBV. These patients were characterized by bone marrow involvement, high incidence of thrombocytopenia, and poor prognosis according to Revised International Prognostic Index and Prognostic Index for Angioimmunoblastic T-cell Lymphoma scores. Conclusion: Assessment of both viremia and serology for EBV could be useful in patients with clinical and laboratory data suggesting lymphoma diagnosis; furthermore, although our data need to be validated in a larger cohort of patients, triple positivity for EBV serology might help to direct the diagnosis toward AITL.

Product ID:

118588

Handle IRIS:

11562/1033129

Last Modified:

November 15, 2022

Bibliographic citation:

Facchinelli, Davide; Parisi, Alice; Krampera, Mauro; Veneri, Dino, Is triple-positive serology for Epstein-Barr virus (VCA-IgG, VCA-IgM, EBNA-IgG) a specific feature of angioimmunoblastic T-cell lymphoma? «Tumori» , vol. 106 , n. 5 , 2020 , pp. 424-426

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