Pubblicazioni

Autori:

Zabotti, Alen; De Lucia, Orazio; Sakellariou, Garifallia; Batticciotto, Alberto; Cincinelli, Gilberto; Giovannini, Ivan; Idolazzi, Luca; Maioli, Gabriella; Tinazzi, Ilaria; Aletaha, Daniel; De Vita, Salvatore; Marchesoni, Antonio; Smolen, Josef; Iagnocco, Annamaria; Mcgonagle, Dennis; Caporali, Roberto

Titolo:

Predictors, Risk Factors, and Incidence Rates of Psoriatic Arthritis Development in Psoriasis Patients: A Systematic Literature Review and Meta-Analysis

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

RHEUMATOLOGY AND THERAPY

ISSN Rivista:

2198-6576

N° Volume:

8

Numero o Fascicolo:

4

Intervallo pagine:

1519-1534

Parole chiave:

Disease prevention; Early psoriatic arthritis; Psoriasis; Psoriatic arthritis; Systematic review

Breve descrizione dei contenuti:

Background Agreement on how to identify psoriasis (PsO) patients at risk of developing psoriatic arthritis (PsA) is lacking. Objective To identify predictors, risk factors and incidence rate (IR) of PsA development in PsO patients through a systematic literature review (SLR) and meta-analyses (MA). Methods MEDLINE, Embase, and Cochrane databases were searched. Cohort studies were used to assess the predictors, while case-control studies for PsA risk factor determination. Results We screened 4698 articles for eligibility, and 110 underwent a full reading and 26 were finally included. Among skin and nail phenotypes, PsO severity and nail pitting were selected as predictors of PsA development. Furthermore, PsO patients with arthralgia (pooled RR 2.15 [1.16; 3.99]) and/or with imaging-MSK inflammation (pooled RR 3.72 [2.12; 6.51]) were at high risk of PsA. Higher categories of BMI and a family history of PsA were other predictors. In outpatient-based cohort studies, the IR of PsA per 100 patient-years varied from 1.34 to 17.4. Limitations Despite the strength of the overall results, the heterogeneity and the number of the cohort studies could be considered a limitation. Conclusions This study provides a tentative profile of the PsO patient at risk of PsA and will help the design of PsA prevention trials.

Id prodotto:

124030

Handle IRIS:

11562/1054723

ultima modifica:

31 gennaio 2025

Citazione bibliografica:

Zabotti, Alen; De Lucia, Orazio; Sakellariou, Garifallia; Batticciotto, Alberto; Cincinelli, Gilberto; Giovannini, Ivan; Idolazzi, Luca; Maioli, Gabriella; Tinazzi, Ilaria; Aletaha, Daniel; De Vita, Salvatore; Marchesoni, Antonio; Smolen, Josef; Iagnocco, Annamaria; Mcgonagle, Dennis; Caporali, Roberto, Predictors, Risk Factors, and Incidence Rates of Psoriatic Arthritis Development in Psoriasis Patients: A Systematic Literature Review and Meta-Analysis «RHEUMATOLOGY AND THERAPY» , vol. 8 , n. 4 , 2021 , pp. 1519-1534

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo