Publications

Authors:

Zabotti, Alen; De Lucia, Orazio; Sakellariou, Garifallia; Batticciotto, Alberto; Cincinelli, Gilberto; Giovannini, Ivan; Idolazzi, Luca; Maioli, Gabriella; Tinazzi, Ilaria; Aletaha, Daniel; De Vita, Salvatore; Marchesoni, Antonio; Smolen, Josef; Iagnocco, Annamaria; Mcgonagle, Dennis; Caporali, Roberto

Title:

Predictors, Risk Factors, and Incidence Rates of Psoriatic Arthritis Development in Psoriasis Patients: A Systematic Literature Review and Meta-Analysis

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

RHEUMATOLOGY AND THERAPY

ISSN of journal:

2198-6576

N° Volume:

8

Number or Folder:

4

Page numbers:

1519-1534

Keyword:

Disease prevention; Early psoriatic arthritis; Psoriasis; Psoriatic arthritis; Systematic review

Short description of contents:

Background Agreement on how to identify psoriasis (PsO) patients at risk of developing psoriatic arthritis (PsA) is lacking. Objective To identify predictors, risk factors and incidence rate (IR) of PsA development in PsO patients through a systematic literature review (SLR) and meta-analyses (MA). Methods MEDLINE, Embase, and Cochrane databases were searched. Cohort studies were used to assess the predictors, while case-control studies for PsA risk factor determination. Results We screened 4698 articles for eligibility, and 110 underwent a full reading and 26 were finally included. Among skin and nail phenotypes, PsO severity and nail pitting were selected as predictors of PsA development. Furthermore, PsO patients with arthralgia (pooled RR 2.15 [1.16; 3.99]) and/or with imaging-MSK inflammation (pooled RR 3.72 [2.12; 6.51]) were at high risk of PsA. Higher categories of BMI and a family history of PsA were other predictors. In outpatient-based cohort studies, the IR of PsA per 100 patient-years varied from 1.34 to 17.4. Limitations Despite the strength of the overall results, the heterogeneity and the number of the cohort studies could be considered a limitation. Conclusions This study provides a tentative profile of the PsO patient at risk of PsA and will help the design of PsA prevention trials.

Product ID:

124030

Handle IRIS:

11562/1054723

Last Modified:

January 31, 2025

Bibliographic citation:

Zabotti, Alen; De Lucia, Orazio; Sakellariou, Garifallia; Batticciotto, Alberto; Cincinelli, Gilberto; Giovannini, Ivan; Idolazzi, Luca; Maioli, Gabriella; Tinazzi, Ilaria; Aletaha, Daniel; De Vita, Salvatore; Marchesoni, Antonio; Smolen, Josef; Iagnocco, Annamaria; Mcgonagle, Dennis; Caporali, Roberto, Predictors, Risk Factors, and Incidence Rates of Psoriatic Arthritis Development in Psoriasis Patients: A Systematic Literature Review and Meta-Analysis «RHEUMATOLOGY AND THERAPY» , vol. 8 , n. 4 , 2021 , pp. 1519-1534

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