Publications

Authors:

Crisafulli, Ernesto; Gabbiani, Daniele; Magnani, Giulia; Dorelli, Gianluigi; Busti, Fabiana; Sartori, Giulia; Senna, Gianenrico; Girelli, Domenico

Title:

Residual Lung Function Impairment Is Associated with Hyperventilation in Patients Recovered from Hospitalised COVID-19: A Cross-Sectional Study

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF CLINICAL MEDICINE

ISSN of journal:

2077-0383

N° Volume:

10

Number or Folder:

1036

Page numbers:

1-6

Keyword:

COVID-19;; lung function;; hypocapnia;; hyperventilation;; restrictive pattern;; interstitial pneumonia

Short description of contents:

Patients who have recovered from COVID-19 show persistent symptoms and lung function alterations with a restrictive ventilatory pattern. Few data are available evaluating an extended period of COVID-19 clinical progression. The RESPICOVID study has been designed to evaluate patients’ pulmonary damage previously hospitalised for interstitial pneumonia due to COVID-19. We focused on the arterial blood gas (ABG) analysis variables due to the initial observation that some patients had hypocapnia (arterial partial carbon dioxide pressure-PaCO2 ≤ 35 mmHg). Therefore, we aimed to characterise patients with hypocapnia compared to patients with normocapnia (PaCO2 > 35 mmHg). Data concerning demographic and anthropometric variables, clinical symptoms, hospitalisation, lung function and gas-analysis were collected. Our study comprised 81 patients, of whom 19 (24%) had hypocapnia as compared to the remaining (n = 62, 76%), and defined by lower levels of PaCO2, serum bicarbonate (HCO3−), carbon monoxide diffusion capacity (DLCO), and carbon monoxide transfer coefficient (KCO) with an increased level of pH and arterial partial oxygen pressure (PaO2). KCO was directly correlated with PaCO2 and inversely with pH. In our preliminary report, hypocapnia is associated with a residual lung function impairment in diffusing capacity. We focus on ABG analysis’s informativeness in the follow-up of post-COVID patients

Product ID:

124793

Handle IRIS:

11562/1057158

Last Modified:

June 16, 2023

Bibliographic citation:

Crisafulli, Ernesto; Gabbiani, Daniele; Magnani, Giulia; Dorelli, Gianluigi; Busti, Fabiana; Sartori, Giulia; Senna, Gianenrico; Girelli, Domenico, Residual Lung Function Impairment Is Associated with Hyperventilation in Patients Recovered from Hospitalised COVID-19: A Cross-Sectional Study «JOURNAL OF CLINICAL MEDICINE» , vol. 10 , n. 1036 , 2021 , pp. 1-6

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