Pubblicazioni

Autori:

Scambi, Ilaria; Peroni, Daniele; Nodari, Alice; Merigo, Flavia; Benati, Donatella; Boschi, Federico; Mannucci, Silvia; Frontini, Andrea; Visonà, Silvia; Sbarbati, Andrea; Krampera, Mauro; Galiè, Mirco

Titolo:

The transcriptional profile of adipose-derived stromal cells (ASC) mirrors the whitening of adipose tissue with age

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

European Journal of Cell Biology

ISSN Rivista:

0171-9335

N° Volume:

101

Numero o Fascicolo:

151206

Intervallo pagine:

1-11

Parole chiave:

Adipose tissue; Adipose-derived stromal cells; Aging; Beige adipocyte; White adipocyte; microRNA

Breve descrizione dei contenuti:

Multipotent stem cells persist within the stromal vascular fraction (SVF) of adipose tissue during adulthood. These cells, commonly referred to as adipose-derived stromal cells (ASC), have been extensively investigated over the past years as a promising therapeutic tool based on their regenerative and immunomodulatory properties. However, how ASC might mirror the age-related alteration of the fat they reside in remains unclear. Herein, we show that inguinal adipose tissue in mice turns from brown/beige- to white-like with age and resident ASC readily mirror these changes both at mRNA and microRNA transcriptional level. Mechanistically, our data suggest that these brown/age-related changes in ASC transcription rely on changes in the activity of E2F1 and NFkB transcription factors.

Pagina Web:

https://doi.org/10.1016/j.ejcb.2022.151206

Id prodotto:

124941

Handle IRIS:

11562/1057837

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Scambi, Ilaria; Peroni, Daniele; Nodari, Alice; Merigo, Flavia; Benati, Donatella; Boschi, Federico; Mannucci, Silvia; Frontini, Andrea; Visonà, Silvia; Sbarbati, Andrea; Krampera, Mauro; Galiè, Mirco, The transcriptional profile of adipose-derived stromal cells (ASC) mirrors the whitening of adipose tissue with age «European Journal of Cell Biology» , vol. 101 , n. 151206 , 2022 , pp. 1-11

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