Publications

Authors:

Mantovani, Alessandro; Zusi, Chiara; Lunardi, Gianluigi; Bonapace, Stefano; Lippi, Giuseppe; Maffeis, Claudio; Targher, Giovanni

Title:

Association between KLF6 rs3750861 polymorphism and plasma ceramide concentrations in post-menopausal women with type 2 diabetes

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Nutrition in Metabolic and Cardiovascular Diseases

ISSN of journal:

0939-4753

N° Volume:

32

Number or Folder:

5

Page numbers:

1283-1287

Keyword:

Ceramides; KLF6; T2DM; Type 2 diabetes; rs3750861

Short description of contents:

Background and aim: Based on the emerging role of Kruppel-like factor 6 (KLF6) in lipid metabolism, we examined whether there is a relationship between the KLF6 rs3750861 genetic variant and plasma ceramide levels in people with type 2 diabetes mellitus (T2DM). Methods and result: We measured six previously identified plasma ceramides, which have been associated with increased cardiovascular risk [Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d18:1/22:0), Cer(d18:1/24:0) and Cer(d18:1/24:1)] amongst 101 Caucasian post-menopausal women with T2DM, who consecutively attended our diabetes outpatient service during a 3-month period. Plasma ceramides were measured by targeted liquid chromatography-tandem mass spectrometry assay. Genotyping of the KLF6 rs3750861 polymorphism was performed by TaqMan-Based RT-PCR system. Overall, 87 (86.1%) patients had KLF6 rs3750861 C/C genotype and 14 (13.9%) had C/T or T/T genotypes. After adjustment for age, diabetes-related variables, use of lipid-lowering drugs and other potential confounders, patients with C/T or T/T genotypes had higher plasma Cer(d18:1/18:0) (0.159 ± 0.05 vs. 0.120 ± 0.04 μmol/L, p = 0.012), Cer(d18:1/20:0) (0.129 ± 0.04 vs. 0.098 ± 0.03 μmol/L, p = 0.008), and Cer(d18:1/24:1) (1.236 ± 0.38 vs. 0.978 ± 0.36 μmol/L, p = 0.032) compared with those with C/C genotype. Conclusions: The C/T or T/T genotypes of rs3750861 in the KLF6 gene were closely associated with higher levels of specific plasma ceramides in post-menopausal women with T2DM.

Web page:

https://doi.org/10.1016/j.numecd.2022.01.037

Product ID:

125225

Handle IRIS:

11562/1059269

Last Modified:

November 15, 2022

Bibliographic citation:

Mantovani, Alessandro; Zusi, Chiara; Lunardi, Gianluigi; Bonapace, Stefano; Lippi, Giuseppe; Maffeis, Claudio; Targher, Giovanni, Association between KLF6 rs3750861 polymorphism and plasma ceramide concentrations in post-menopausal women with type 2 diabetes «Nutrition in Metabolic and Cardiovascular Diseases» , vol. 32 , n. 5 , 2022 , pp. 1283-1287

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