Publications

Authors:

Vianello, Andrea; Guarnieri, Gabriella; Braccioni, Fausto; Molena, Beatrice; Lococo, Sara; Achille, Alessia; Lionello, Federico; Salviati, Leonardo; Caminati, Marco; Senna, Gianenrico

Title:

Correlation between α1-Antitrypsin Deficiency and SARS-CoV-2 Infection: Epidemiological Data and Pathogenetic Hypotheses

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF CLINICAL MEDICINE

ISSN of journal:

2077-0383

N° Volume:

10

Number or Folder:

19

Page numbers:

4493-4497

Keyword:

COVID-19; SARS-CoV-2; genetics; α1-antitrypsin deficiency

Short description of contents:

: The most common hereditary disorder in adults, α1-antitrypsin deficiency (AATD), is characterized by reduced plasma levels or the abnormal functioning of α1-antitrypsin (AAT), a major human blood serine protease inhibitor, which is encoded by the SERine Protein INhibitor-A1 (SERPINA1) gene and produced in the liver. Recently, it has been hypothesized that the geographic differences in COVID-19 infection and fatality rates may be partially explained by ethnic differences in SERPINA1 allele frequencies. In our review, we examined epidemiological data on the correlation between the distribution of AATD, SARS-CoV-2 infection, and COVID-19 mortality rates. Moreover, we described shared pathogenetic pathways that may provide a theoretical basis for our epidemiological findings. We also considered the potential use of AAT augmentation therapy in patients with COVID-19.

Product ID:

125599

Handle IRIS:

11562/1060983

Last Modified:

November 8, 2022

Bibliographic citation:

Vianello, Andrea; Guarnieri, Gabriella; Braccioni, Fausto; Molena, Beatrice; Lococo, Sara; Achille, Alessia; Lionello, Federico; Salviati, Leonardo; Caminati, Marco; Senna, Gianenrico, Correlation between α1-Antitrypsin Deficiency and SARS-CoV-2 Infection: Epidemiological Data and Pathogenetic Hypotheses «JOURNAL OF CLINICAL MEDICINE» , vol. 10 , n. 19 , 2021 , pp. 4493-4497

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo